Lactate dehydrogenase activity drives hair follicle stem cell activation

Lactate Leading To Hair Loss: What do you guys think (link below):
https://www.hairlosstalk.com/interact/threads/further-evidence-of-decreased-lactate-leading-to-hair-loss.107855/

Lactate dehydrogenase activity drives hair follicle stem cell activation
Nat Cell Biol. 2017 Aug 14

Flores A1,2,3, Schell J4, Krall AS5, Jelinek D1, Miranda M1, Grigorian M6, Braas D5,7, White AC8, Zhou JL9, Graham NA5,9, Graeber T5,10, Seth P11, Evseenko D12, Coller HA1,2,3,13,14, Rutter J4,15, Christofk HR2,5,7,13,14, Lowry WE1,2,3,13.

Abstract

Although normally dormant, hair follicle stem cells (HFSCs) quickly become activated to divide during a new hair cycle. The quiescence of HFSCs is known to be regulated by a number of intrinsic and extrinsic mechanisms. Here we provide several lines of evidence to demonstrate that HFSCs utilize glycolytic metabolism and produce significantly more lactate than other cells in the epidermis. Furthermore, lactate generation appears to be critical for the activation of HFSCs as deletion of lactate dehydrogenase (Ldha) prevented their activation. Conversely, genetically promoting lactate production in HFSCs through mitochondrial pyruvate carrier 1 (Mpc1) deletion accelerated their activation and the hair cycle. Finally, we identify small molecules that increase lactate production by stimulating Myc levels or inhibiting Mpc1 carrier activity and can topically induce the hair cycle. These data suggest that HFSCs maintain a metabolic state that allows them to remain dormant and yet quickly respond to appropriate proliferative stimuli.

CampOfDavid,

Good find.  Thank you.  I guess that thread was created on HLT in response to this study, for which there is another thread there.  I hope you don't mind but I created a new thread for the study and merged yours into it.