Search
Check Out Our Sponsors
Latest topics
FOXC1 maintains the hair follicle stem cell niche and governs stem cell quiescence to preserve long-term tissue-regenerating potential.
Page 1 of 1
FOXC1 maintains the hair follicle stem cell niche and governs stem cell quiescence to preserve long-term tissue-regenerating potential.
Proc Natl Acad Sci U S A. 2016 Feb 24. pii: 201601569. [Epub ahead of print]
FOXC1 maintains the hair follicle stem cell niche and governs stem cell quiescence to preserve long-term tissue-regenerating potential.
Adult tissue stem cells (SCs) reside in niches, which orchestrate SC behavior. SCs are typically used sparingly and exist in quiescence unless activated for tissue growth. Whether parsimonious SC use is essential to conserve long-term tissue-regenerating potential during normal homeostasis remains poorly understood. Here, we examine this issue by conditionally ablating a key transcription factor Forkhead box C1 (FOXC1) expressed in hair follicle SCs (HFSCs). FOXC1-deficient HFSCs spend less time in quiescence, leading to markedly shortened resting periods between hair cycles. The enhanced hair cycling accelerates HFSC expenditure, and impacts hair regeneration in aging mice. Interestingly, although FOXC1-deficient HFs can still form a new bulge that houses HFSCs for the next hair cycle, the older bulge is left unanchored. As the new hair emerges, the entire old bulge, including its reserve HFSCs and SC-inhibitory inner cell layer, is lost. We trace this mechanism first, to a marked increase in cell cycle-associated transcripts upon Foxc1 ablation, and second, to a downstream reduction in E-cadherin-mediated inter-SC adhesion. Finally, we show that when the old bulge is lost with each hair cycle, overall levels of SC-inhibitory factors are reduced, further lowering the threshold for HFSC activity. Taken together, our findings suggest that HFSCs have restricted potential in vivo, which they conserve by coupling quiescence to adhesion-mediated niche maintenance, thereby achieving long-term tissue homeostasis.
Full Study: http://www.pnas.org/content/early/2016/02/23/1601569113.long
FOXC1 maintains the hair follicle stem cell niche and governs stem cell quiescence to preserve long-term tissue-regenerating potential.
Adult tissue stem cells (SCs) reside in niches, which orchestrate SC behavior. SCs are typically used sparingly and exist in quiescence unless activated for tissue growth. Whether parsimonious SC use is essential to conserve long-term tissue-regenerating potential during normal homeostasis remains poorly understood. Here, we examine this issue by conditionally ablating a key transcription factor Forkhead box C1 (FOXC1) expressed in hair follicle SCs (HFSCs). FOXC1-deficient HFSCs spend less time in quiescence, leading to markedly shortened resting periods between hair cycles. The enhanced hair cycling accelerates HFSC expenditure, and impacts hair regeneration in aging mice. Interestingly, although FOXC1-deficient HFs can still form a new bulge that houses HFSCs for the next hair cycle, the older bulge is left unanchored. As the new hair emerges, the entire old bulge, including its reserve HFSCs and SC-inhibitory inner cell layer, is lost. We trace this mechanism first, to a marked increase in cell cycle-associated transcripts upon Foxc1 ablation, and second, to a downstream reduction in E-cadherin-mediated inter-SC adhesion. Finally, we show that when the old bulge is lost with each hair cycle, overall levels of SC-inhibitory factors are reduced, further lowering the threshold for HFSC activity. Taken together, our findings suggest that HFSCs have restricted potential in vivo, which they conserve by coupling quiescence to adhesion-mediated niche maintenance, thereby achieving long-term tissue homeostasis.
Full Study: http://www.pnas.org/content/early/2016/02/23/1601569113.long
_________________
My regimen
http://www.immortalhair.org/mpb-regimen
Now available for consultation (hair and/or health)
http://www.immortalhair.org/health-consultation
Similar topics
» Photoactivation of ROS Production in Situ Transiently Activates Cell Proliferation in Mouse Skin and in the hair Follicle Stem Cell Niche Promoting Hair Growth and Wound Healing
» Niche-induced cell death and epithelial phagocytosis regulate hair follicle stem cell pool.
» Hair follicle stem cell marker nestin expression in regenerating hair follicles of patients with alopecia areata.
» Lymphatic vessels interact dynamically with the hair follicle stem cell niche during skin regeneration in vivo.
» Foxc1 reinforces quiescence in self-renewing hair follicle stem cells.
» Niche-induced cell death and epithelial phagocytosis regulate hair follicle stem cell pool.
» Hair follicle stem cell marker nestin expression in regenerating hair follicles of patients with alopecia areata.
» Lymphatic vessels interact dynamically with the hair follicle stem cell niche during skin regeneration in vivo.
» Foxc1 reinforces quiescence in self-renewing hair follicle stem cells.
Page 1 of 1
Permissions in this forum:
You cannot reply to topics in this forum
|
|
Today at 6:36 pm by grail
» Road to recovery - my own log of everything I'm currently trying for HL
Tue Apr 30, 2024 1:55 pm by JtheDreamer
» Medical Coder During C0NV!D
Sat Apr 27, 2024 4:00 pm by CausticSymmetry
» *The first scientific evidence in 2021 that viruses do not exist*
Fri Apr 26, 2024 12:44 pm by CausticSymmetry
» Potential Natural Products Regulation of Molecular Signaling Pathway in Dermal Papilla Stem Cells
Wed Apr 17, 2024 7:44 am by CausticSymmetry
» Breast Biopsy
Sun Apr 14, 2024 2:23 am by shaftless
» Sorry if brought up before but: Best topical to help aid in breaking up fibrosis?
Sat Apr 13, 2024 2:51 am by Hoppipolla
» solar eclipse on april 8
Thu Apr 11, 2024 4:04 am by shaftless
» Role and Mechanisms of Phytochemicals in Hair Growth and Health
Wed Apr 10, 2024 4:20 am by CausticSymmetry