Mitochondrial aerobic respiration is activated during hair follicle stem cell differentiation, and its dysfunction retards hair regeneration.

PeerJ. 2016 May 3;4:e1821. doi: 10.7717/peerj.1821. eCollection 2016.
Mitochondrial aerobic respiration is activated during hair follicle stem cell differentiation, and its dysfunction retards hair regeneration.
Tang Y1, Luo B2, Deng Z1, Wang B1, Liu F1, Li J1, Shi W1, Xie H1, Hu X3, Li J1.

Background. Emerging research revealed the essential role of mitochondria in regulating stem/progenitor cell differentiation of neural progenitor cells, mesenchymal stem cells and other stem cells through reactive oxygen species (ROS), Notch or other signaling pathway. Inhibition of mitochondrial protein synthesis results in hair loss upon injury. However, alteration of mitochondrial morphology and metabolic function during hair follicle stem cells (HFSCs) differentiation and how they affect hair regeneration has not been elaborated upon. Methods. We compared the difference in mitochondrial morphology and activity between telogen bulge cells and anagen matrix cells. Expression levels of mitochondrial ROS and superoxide dismutase 2 (SOD2) were measured to evaluate redox balance. In addition, the level of pyruvate dehydrogenase kinase (PDK) and pyruvate dehydrogenase (PDH) were estimated to present the change in energetic metabolism during differentiation. To explore the effect of the mitochondrial metabolism on regulating hair regeneration, hair growth was observed after application of a mitochondrial respiratory inhibitor upon hair plucking. Results. During HFSCs differentiation, mitochondria became elongated with more abundant organized cristae and showed higher activity in differentiated cells. SOD2 was enhanced for redox balance with relatively stable ROS levels in differentiated cells. PDK increased in HFSCs while differentiated cells showed enhanced PDH, indicating that respiration switched from glycolysis to oxidative phosphorylation during differentiation. Inhibiting mitochondrial respiration in differentiated hair follicle cells upon hair plucking repressed hair regeneration in vivo. Conclusions. Upon HFSCs differentiation, mitochondria are elongated with more abundant cristae and show higher activity, accompanying with activated aerobic respiration in differentiated cells for higher energy supply. Also, dysfunction of mitochondrial respiration delays hair regeneration upon injury.

Full study:

https://peerj.com/articles/1821/

What does this mean CS?

CampOfDavid wrote:What does this mean CS?

Preserving the integrity of the mitochondria (energy producing organelle of the cell) will help reduce hair loss. This paper is more of continued follow-up research on how affecting this organelle can negatively effect the hair.

Thanks for the reply
What are your thoughts on the best way to go about this?

CampOfDavid wrote:Thanks for the reply
What are your thoughts on the best way to go about this?

Here is a related article (from my blog).

http://www.immortalhair.org/apps/blog/show/43855869-energy-supplement-delays-premature-aging-in-hair-follicle-cells

Would this be a effective supplement to help with this?: http://www.swansonvitamins.com/swanson-premium-choline-inositol-250-250-mg-250-caps

I did some studies on stem cells, body regeneration and aging.  Basically the study is talking about the need for oxygenation to be properly supplied to the mitochondria to produce the correct energy for hair regrow.  Stem cells need to be assigned a type/task to become functional, and without proper oxygenation they are not as effective to regrow hairs that were plucked.  

There are many ways to assure that the blood is properly supplied with oxygen.  Everything from exercise to nutrition like iron or capsicum are a few of the ways.  For a standard scalp improvement,  enzyme cleanse topicals or massage to assist in moving oxygen rich blood may help.

I am going to repost this writing that I posted on the DT-CPR thread as it may assist somebody in the context of this thread. It is partly related to people with diabetes,  but actually I think the benefits of cinnamon are useful for normal people,  and the studies are highlighting how the benefits directly helped diabetics.

I wrote and edited -


 Be really careful mixing cinnamon oil and water. If you take a shower or sweat before applying the oil,  it can be 5 alarm hot on your skull. Dilution is recommended to make a topical to treat the scalp 

  There are many  special attributes of cinnamon.

http://care.diabetesjournals.org/content/26/12/3215

"The results of this study demonstrate that intake of 1, 3, or 6 g of cinnamon per day reduces serum glucose, triglyceride, LDL cholesterol, and total cholesterol in people with type 2 diabetes and suggest that the inclusion of cinnamon in the diet of people with type 2 diabetes will reduce risk factors associated with diabetes and cardiovascular diseases. "

It helps regulate glucose levels in the blood and reduces triglycerides and total cholesterol.  The glucose makes me think about how another anti-diabetes metformin  does something similar by regulating glucose

http://www.worldhealth.net/news/metformin-may-promote-anti-aging/

"Metformin increases the number of oxygen molecules released into a cell, which appears to boost robustness and longevity. It works by suppressing glucose production in the liver and increasing insulin sensitivity, therefore benefitting patients with type 2 diabetes. "

This recent study that CS posted about cellular oxygenation and how it effects the mitochondria of stem cells to properly regrow hair. The blend of proper mitochondrial processes of glucose processing and oxygenation are the reason that these components are linked to anti aging and cancer prevention.



So applying these ideas, the benefits of cinnamon in this DT-CPR application may have many benefits including possibly removing the sticky plaque ( triglycerides and cholesterol )  that would bind the calcification to the capillaries (assisting in unblocking them). Also proper glucose regulation may improve scalp and mitochondrial conditions of the follicles .

Diabetes is linked to poor circulation problems (to the point of amputation via tissue degradation) ,  perhaps MPB could be a form of local diabetes symptoms where circulation problems are brought on by mitochondrial dysfunction and depleted skin conditions. 

I could detail this theory with more documentation links and elaborate more on telomeres  in the mitochondria and the links to aging and dying cells.  For now I will only add that the components of this protocol (DT-CPR) were specifically chosen and few others have done the entire recommend protocol .