CKST: Cheap Kitchen Sink Topical

Can we come up with a cheap practical and convenient topical made of multiple ingredients?

Maybe each ingredient could be present in relatively smaller concentration than if it was a single active ingredient play, not going overboard with any single one of the ingredients.

The chosen ingredients would each have the following properties:

1. very cheap individually
   
2. highly soluble
   
3. stable in solution even when mixed with several other things
   
4. low reactivity
   
5. very safe from systemic sides (or in a concentration adjusted for safety)
   
6. non interfering
   
7. [extra, for some of us]natural
   

If something doesn't pass any of the "tests" above, it should be dropped from the list. For example, exogenous PGE2 doesn't pass the test number 1, being expensive. For some of us, there might be an extra "test" to be passed, which is being naturals. Just drop all the non-natural stuff from the list. For example Minoxdil 5% doesn't pass test number 2 and test number 5, and the extra test number 7. But Minoxidil 1% would pass all tests except for the extra test number 7. Melatonin 10% would not pass test number 2, being at saturation in ethanol, but Melatonin 0.3% would pass all tests. Of course our vehicle doesn't need to be pure ethanol, but I am just trying to keep the example simple.

As a strawman proposal I am thinking of mixing the following things. Please help me short-list them to fewer and fewer ones, which would make things simpler. I will edit and update the list, striking them through and adding the reason next to them. I can also add new entries if you have good suggestions. In the list, there's also stuff that I don't like, for example Adenosine. I am just putting it there, but if enough people don't like it, I will be very glad to remove it. Everything that is there for now is there just in order to provoke thoughts.

• VPA
  
• Sucralfate
  
• Extra Virgin Castor Oil - no more than 3-5% because of viscosity
  
• Mucopolysaccharides a la Surge Plus 14 Hair Revitalizer / NetWurks Xcel-21 Hair Growth Revitalizer
  
• Adelmidrol 2% -OR- Palmitoylethanolamide 2% + DMSO
  
• MSM
  
• Calcitirol/Calcipotriol
  
• L-ascorbic acid 2-phosphate
  
• pyridoxal 5-phosphate
  
• melatonin 0.3-0.5% in the evening version of the topical
  
• caffeine in the morning version of the topical -OR- adenosine in both the morning
  
• version and the evening version
  
• polysorbate 80 (as per the original Finnish study)
  
• -EITHER- zinc sulfate -OR- ZnP -OR- minoxidil 1-2% -OR- minoxidil sulphate 1-2% -OR- minoxidil 1% + minoxidil sulphate 1% -OR- zinc sulfate + ZnP
  
• essential oils of rosemary, peppermint, thyme, lavender, lemon, melaleuca, cedarwood, ylang ylang
  
• betamethasone + isotretinoin
  
• betasitosterol - not in solution, but rather in suspension thanks to the polysorbate 80
  

I would not use any form of Minoxidil together with caffeine or zinc/ZnP in the same topical or any other topical or shampoo.

Pyridoxal 5-phosphate + Zinc sulfate + Betasitosterol + Polysorbate 80 have already been successfully used together in Super Zix II.

What would you take out? What would you add?

thank you!

First solution that I compounded today with my magnetic stirrer:

• 20ml of 190-proof grain alcohol
  
• 300mg (1.5%) MSM
  
• 6 drops each of rosemary verbenone, lemon, peppermint, lavender essential oils
  
• 1ml (5%) extra virgin castor oil
  

The solution has a clear color and seems very nice and refreshing when applied. Can't add any DMSO for now, as I am keeping it in an old dermenodex plastic bottle.

Will add more stuff from the kitchen sink list in the next days and report back.

Hi,

I noticed you considered Palmitoylethanolamide/PEA, have you tried it or heard anyone using it? Do you know if its said PGD2 decreasing is due to COX inhibition or some other way where PGE2 would decrease as well?

Thanks