Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition.

Nat Med. 2014 Aug 17. doi: 10.1038/nm.3645.
Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition.
Xing L1, Dai Z2, Jabbari A2, Cerise JE3, Higgins CA4, Gong W4, de Jong A4, Harel S4, DeStefano GM5, Rothman L4, Singh P4, Petukhova L4, Mackay-Wiggan J4, Christiano AM6, Clynes R7.

Alopecia areata (AA) is a common autoimmune disease resulting from damage of the hair follicle by T cells. The immune pathways required for autoreactive T cell activation in AA are not defined limiting clinical development of rational targeted therapies. Genome-wide association studies (GWAS) implicated ligands for the NKG2D receptor (product of the KLRK1 gene) in disease pathogenesis. Here, we show that cytotoxic CD8+NKG2D+ T cells are both necessary and sufficient for the induction of AA in mouse models of disease. Global transcriptional profiling of mouse and human AA skin revealed gene expression signatures indicative of cytotoxic T cell infiltration, an interferon-γ (IFN-γ) response and upregulation of several γ-chain (γc) cytokines known to promote the activation and survival of IFN-γ-producing CD8+NKG2D+ effector T cells. Therapeutically, antibody-mediated blockade of IFN-γ, interleukin-2 (IL-2) or interleukin-15 receptor β (IL-15Rβ) prevented disease development, reducing the accumulation of CD8+NKG2D+ T cells in the skin and the dermal IFN response in a mouse model of AA. Systemically administered pharmacological inhibitors of Janus kinase (JAK) family protein tyrosine kinases, downstream effectors of the IFN-γ and γc cytokine receptors, eliminated the IFN signature and prevented the development of AA, while topical administration promoted hair regrowth and reversed established disease. Notably, three patients treated with oral ruxolitinib, an inhibitor of JAK1 and JAK2, achieved near-complete hair regrowth within 5 months of treatment, suggesting the potential clinical utility of JAK inhibition in human AA.

Hey CS, do you think that maybe has something in common with MPB?

TNT wrote:Hey CS, do you think that maybe has something in common with MPB?

Not so much, however some are unlucky enough to have both AGA and the "autoimmune based hair loss"

Thanks for making that point, CS. There can be crossover, and I believe etiologically there are some commonalities. I've had dermatologists confirm that portions of my loss, particularly the areas that I lost the most rapidly, showed AA-like immune cell activity. I didn't lose the eyebrows or anything like that, but what I noticed is that certain "patches", or regions of my hair thinned to a far greater extent than the rest of the scalp, to the point where the hair was so fine you could barely see it. And the color changed as well, taking on an almost bleached appearance.

Is there a supplement that can be taken that will address what was found in this study on AA?

jk120 wrote:Is there a supplement that can be taken that will address what was found in this study on AA?

Yes, it is covered in this thread:

https://immortalhair.forumotion.com/t10342-uh-oh-here-we-go

CausticSymmetry wrote:

jk120 wrote:Is there a supplement that can be taken that will address what was found in this study on AA?

Yes, it is covered in this thread:

https://immortalhair.forumotion.com/t10342-uh-oh-here-we-go

I have to bump this to ask, what supps would you recommend specifically for AA? Can you give me some brand or link to iherb? Thanks.

CausticSymmetry wrote:

jk120 wrote:Is there a supplement that can be taken that will address what was found in this study on AA?

Yes, it is covered in this thread:

https://immortalhair.forumotion.com/t10342-uh-oh-here-we-go

so the guy from the study cured his hairloss forever or he has to take this drug for a long time?

MikeBison wrote:

CausticSymmetry wrote:

jk120 wrote:Is there a supplement that can be taken that will address what was found in this study on AA?

Yes, it is covered in this thread:

https://immortalhair.forumotion.com/t10342-uh-oh-here-we-go

I have to bump this to ask, what supps would you recommend specifically for AA? Can you give me some brand or link to iherb? Thanks.

I think JAK inhibitors work well in this regard. Antioxidant boost consist all what's worth in this regard, i believe... Would say it's important also to break scar tissue with MSM, and supply vitamin D...

Beebrox wrote:

MikeBison wrote:

CausticSymmetry wrote:

jk120 wrote:Is there a supplement that can be taken that will address what was found in this study on AA?

Yes, it is covered in this thread:

https://immortalhair.forumotion.com/t10342-uh-oh-here-we-go

I have to bump this to ask, what supps would you recommend specifically for AA? Can you give me some brand or link to iherb? Thanks.

I think JAK inhibitors work well in this regard. Antioxidant boost consist all what's worth in this regard, i believe... Would say it's important also to break scar tissue with MSM, and supply vitamin D...

Ok, I didn't understand that Antioxidant boost is the brand, I'll check it out.