CS @ I need your knowledge. Vit B5 hairloss theory

I've been following and a thread on acne.com about hairloss when megadosing vitamin b5.
 
I've seen that you have Amazing knowledge and wanna know if you know anything about this. Would mean alot if you could help. Thanks

The majority in that thread seems to suffer the same things:
Hairloss, dry hair, itchy scalp. Seb.dermatitis like symptoms


The OP in that thread wrote this today.



New Theory: Lipid Metabolism



What has transpired



Over the past 2 year multiple people have reported hair loss from megadosing b5 for short amounts of time. Many users have been tested with little conclusive evidence, most lab values coming back within normal range.  Those values out of range do not match other users results. Furthermore, It is hard to theorize why b5 can cause complete endocrine disaster involving cortisol, dht, adrenals, or the thyroid in a matter of a few weeks.



Back to basics



Coenzyme A is active in both fatty acid metabolism and sex hormone synthesis. Dr. Lit-Hung Leung theorized correctly that when the pool of coenzyme A becomes reduced, the body prioritizes sex hormone synthesis. This leads to excess fat, which is secreted as sebum and eventually leads to acne. By megadosing Vitamin B5, (a component of Coenyzme A not made by the body,) the body would no longer be deficient, thus now being able to metabolize the excess fat banishing acne. Most users did experience a dramatic improvement in our skin, unfortunately accompanied by hair loss.  Discontinuing B5 did not remedy the hair loss, for many users hair loss has gone on for years.



What’s going on?



One of the primary purposes of the skin is water retention. As expected, many lipids are contained in the skin to facilitate this purpose. When lipid metabolism goes wrong, both the skin and hair follicle can become faulty. In one paper it was found that the loss of the acyl-CoA binding protein (Acbp) results in fatty acid metabolism abnormalities in mouse hair and skin. Another paper asks the question “What is the link between altered lipid metabolism, inflammation, and disrupted hair follicles? The three studies clearly show an apparent toxic effect on hair follicle cycling—the pathology is clear. The role of these lipid metabolic pathways in normal hair follicle biology and the mechanism by which changes in these pathways cause the pathological phenotype remain unclear, and such questions need attention.” There are other papers (links at end) all pointing in the same direction-à lipid metabolism.

I propose the following theory: megadosing b5 altered lipid metabolism, triggering hair loss.  I will go even further and say, I believe altered lipid metabolism is actually the cause of male pattern baldness, but that it is triggered by genetics rather then B5 megadosing. This explains why the hair loss happens immediately, because the massive amount of COA alters lipid metabolism immediately. This was the original purpose of taking B5, was it not? There is no need to involve the thyroid, cortisols, etc. Occam’s razor applies.





What about DHT?



DHT is the soldier, not general is this war. You had DHT all your life; it is only when your hair follicles became sensitive to it that the hair loss began. Now many users have had success with nirozal, minox, propecia and Avodart. This will slow down the hair loss, but the root cause still needs to be addressed.



Potential NON-DHT Cure



If lipid metabolism is the cause, let us go straight to the lipids. Here is a presentation on adipose-derived stem cells. Listed below is also a link to a clinic in Boston for this treatment, cost $2500. There also might be a clinic in Japan or South Korea.



http://www.balanceha...-stem-cells.pdf



http://www.nehair.com/stem-cells





References:



http://www.ncbi.nlm..../?report=reader



http://www.ncbi.nlm....PMC2923384/#R15



http://www.ncbi.nlm....les/PMC2929004/

Elessar - For me, a lipid problem usually means a nutrient problem. Using a pharmacological dose of an isolated, albeit activated nutrient may cause side-effects.

The entire B-complex is needed. Also there are other nutrients that are needed.

Also, there's a lot of confusion surrounding DHT itself, which is another matter. Probably the worst thing is that labs are looked at without an understanding of the entire system. The root of the problem is often ignored in favor of a particular lab value being out of range or with the use of an isolated fraction.

I might look at single-nucleotide polymorphisms (SNPs), but ultimately a full medical history and identification of the origin of where the underlying inflammation problem exists.