Chrysanthemum morifolium

Studies on chemical constituents in Huangjuhua (flowers of Chrysanthemum morifolium)] [Article in Chinese]

Wang YJ, Yang XW, Guo QS.

Institute of Chinese Medicinal Materials, Nanjing Agricultural University, Nanjing 210095, China.

OBJECTIVE: To study the chemical constituents in Huangjuhua (flowers of Chrysanthemum morifolium). METHOD: The chemical constituents were isolated by various column chromatographic methods and structurally elucidated by NMR and MS evidences. RESULT: Eleven compounds were obtained and identified as luteolin (1), quercetin (2), acacetin 7-O-beta-D-(3"-acetyl) -glucopyranoside (3), luteolin 7-O-beta-D-(6"-acetyl)-glucopyranoside (4), hesperetin 7-O-beta-D-glucopyranoside (5), acacetin 7-O-beta-D-glucopyranoside (6), diosmetin 7-O-beta-D-glucopyranoside (7), apigenin 7-O-beta-D-glucopyranoside (, hesperidin (9), linarin (10), and luteolin 7-O-beta-D-glucopyranoside (11). CONCLUSION: Compounds 4, 5 were isolated from the plant for the first time.

PMID: 18536375 [PubMed - indexed for MEDLINE]

It has high absorption rates of apigenin

Absorption and Excretion of Luteolin and Apigenin in Rats after Oral Administration of Chrysanthemum morifolium Extract

Chrysanthemum morifolium extract (CME) has the protective effect on cardiovascular diseases. Luteolin and apigenin are two major bioactive components in vivo when CME is orally administrated to experimental animal. The present paper shows the study of the absorption and excretion of luteolin and apigenin in rats after a single oral dose of CME (200 mg/kg). The levels of luteolin and apigenin in plasma, urine, feces, and bile were measured by HPLC after deconjugation with hydrochloric acid or ß-glucuronidase/sulfatase. The results showed that the plasma concentrations of luteolin and apigenin reached the highest peak level at 1.1 and 3.9 h after dosing, respectively. The area under the concentration-time curves (AUC) for luteolin and apigenin were 23.03 and 237.6 µg h mL-1, respectively. The total recovery of the dose was 37.9% (6.6% in urine; 31.3% in feces) for luteolin and 45.2% (16.6% in urine; 28.6% in feces) for apigenin. The cumulative luteolin and apigenin excreted in the bile was 2.05% and 6.34% of the dose, respectively. All of the results suggest apigenin may be absorbed more efficiently than luteolin in CME in rats, and both luteolin and apigenin have a slow elimination phase, with a quick absorption, so a possible accumulation of the two flavonoids in the body can be hypothesized.