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Adenosine increases anagen hair growth and thick hairs in Japanese women with female pattern hair loss
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ganny
CausticSymmetry
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Adenosine increases anagen hair growth and thick hairs in Japanese women with female pattern hair loss
J Dermatol. 2008 Dec;35(12):763-7.
Adenosine increases anagen hair growth and thick hairs in Japanese women with female pattern hair loss: A pilot, double-blind, randomized, placebo-controlled trial.
Oura H, Iino M, Nakazawa Y, Tajima M, Ideta R, Nakaya Y, Arase S, Kishimoto J.
Department of Dermatology, School of Medicine, University of Tokushima, Tokushima, Japan.
Adenosine upregulates the expression of vascular endothelial growth factor and fibroblast growth factor-7 in cultured dermal papilla cells. It has been shown that, in Japanese men, adenosine improves androgenetic alopecia due to the thickening of thin hair due to hair follicle miniaturization. To investigate the efficacy and safety of adenosine treatment to improve hair loss in women, 30 Japanese women with female pattern hair loss were recruited for this double-blind, randomized, placebo-controlled study. Volunteers used either 0.75% adenosine lotion or a placebo lotion topically twice daily for 12 months. Efficacy was evaluated by dermatologists and by investigators and in phototrichograms. As a result, adenosine was significantly superior to the placebo according to assessments by dermatologists and investigators and by self-assessments. Adenosine significantly increased the anagen hair growth rate and the thick hair rate. No side-effects were encountered during the trial. Adenosine improved hair loss in Japanese women by stimulating hair growth and by thickening hair shafts. Adenosine is useful for treating female pattern hair loss in women as well as androgenetic alopecia in men.
Adenosine increases anagen hair growth and thick hairs in Japanese women with female pattern hair loss: A pilot, double-blind, randomized, placebo-controlled trial.
Oura H, Iino M, Nakazawa Y, Tajima M, Ideta R, Nakaya Y, Arase S, Kishimoto J.
Department of Dermatology, School of Medicine, University of Tokushima, Tokushima, Japan.
Adenosine upregulates the expression of vascular endothelial growth factor and fibroblast growth factor-7 in cultured dermal papilla cells. It has been shown that, in Japanese men, adenosine improves androgenetic alopecia due to the thickening of thin hair due to hair follicle miniaturization. To investigate the efficacy and safety of adenosine treatment to improve hair loss in women, 30 Japanese women with female pattern hair loss were recruited for this double-blind, randomized, placebo-controlled study. Volunteers used either 0.75% adenosine lotion or a placebo lotion topically twice daily for 12 months. Efficacy was evaluated by dermatologists and by investigators and in phototrichograms. As a result, adenosine was significantly superior to the placebo according to assessments by dermatologists and investigators and by self-assessments. Adenosine significantly increased the anagen hair growth rate and the thick hair rate. No side-effects were encountered during the trial. Adenosine improved hair loss in Japanese women by stimulating hair growth and by thickening hair shafts. Adenosine is useful for treating female pattern hair loss in women as well as androgenetic alopecia in men.
Re: Adenosine increases anagen hair growth and thick hairs in Japanese women with female pattern hair loss
This is exciting! I feel like some of the best research is coming out of Japan. Is this available in some form here?
ganny- Posts : 107
Join date : 2008-07-16
Re: Adenosine increases anagen hair growth and thick hairs in Japanese women with female pattern hair loss
ganny - It should be, and I agree, it seems that most of the good stuff comes from Japan. Sure glad patent medicine doesn't have a monopoly on research.
Re: Adenosine increases anagen hair growth and thick hairs in Japanese women with female pattern hair loss
Gots to get me some adenosine...
NewReg- Posts : 299
Join date : 2008-11-07
Re: Adenosine increases anagen hair growth and thick hairs in Japanese women with female pattern hair loss
This one sounds familiar. Is this 'Adenosine' really that new?
Too bad the economy in Japan is marked "depression" now.
Too bad the economy in Japan is marked "depression" now.
Misirlou- Posts : 1170
Join date : 2008-07-11
Re: Adenosine increases anagen hair growth and thick hairs in Japanese women with female pattern hair loss
It's not new, just further confirmation.
Here's a link on it that I posted a while back. I'm sure google searches would unearth a lot more on the subject.
http://www.hairlosshelp.com/forums/messageview.cfm?catid=10&threadid=78994&STARTPAGE=1&FTVAR_FORUMVIEWTMP=Linear
Here's a link on it that I posted a while back. I'm sure google searches would unearth a lot more on the subject.
http://www.hairlosshelp.com/forums/messageview.cfm?catid=10&threadid=78994&STARTPAGE=1&FTVAR_FORUMVIEWTMP=Linear
Gibson- Posts : 992
Join date : 2008-07-09
Re: Adenosine increases anagen hair growth and thick hairs in Japanese women with female pattern hair loss
Ganny,
This product/topical matches your inquiry.
http://www.macys.com/catalog/product/index.ognc?ID=226512&PartnerID=FROOGLE&BannerID=PD310
This product/topical matches your inquiry.
http://www.macys.com/catalog/product/index.ognc?ID=226512&PartnerID=FROOGLE&BannerID=PD310
Gibson- Posts : 992
Join date : 2008-07-09
Re: Adenosine increases anagen hair growth and thick hairs in Japanese women with female pattern hair loss
Thread on said product above.
http://www.hairlosshelp.com/forums/messageview.cfm?catid=10&threadid=42194
http://www.hairlosshelp.com/forums/messageview.cfm?catid=10&threadid=42194
Gibson- Posts : 992
Join date : 2008-07-09
Re: Adenosine increases anagen hair growth and thick hairs in Japanese women with female pattern hair loss
Too expensive, we need a cheap copy!
Misirlou- Posts : 1170
Join date : 2008-07-11
Re: Adenosine increases anagen hair growth and thick hairs in Japanese women with female pattern hair loss
and no stellar reviews on that site as of yet.
ganny- Posts : 107
Join date : 2008-07-16
Re: Adenosine increases anagen hair growth and thick hairs in Japanese women with female pattern hair loss
Adenosine increases profibrotic mediators that included TGF-β1, IL-1β, IL-13, plasminogen activator inhibitor-1 (PAI-1), and osteopontin. Since TGF-beta has anti-inflammatory properties the anti-inflammatory action of adenosine is likely at least in part mediated by TGF-beta. Adenosine increases collagen production in order to close the wound. Since it is vital for a living creature to close a wound quickly, fibrotic scars are less of an issue for the body, but closing the wound fast is important.
Do you think long term topical adenosine can cause fibrosis?
Do you think long term topical adenosine can cause fibrosis?
Biffy- Posts : 325
Join date : 2013-03-26
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» Adenosine stimulates growth of dermal papilla and lengthens the anagen phase by increasing the cysteine level via fibroblast growth factors 2 and 7 in an organ culture of mouse vibrissae hair follicles
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