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L-ascorbic acid 2-phosphate represses dickkopf-1 expression
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L-ascorbic acid 2-phosphate represses dickkopf-1 expression
Have we discussed this study earlier? If so I obviously missed it. I probably did
L-ascorbic acid 2-phosphate represses the dihydrotestosterone-induced dickkopf-1 expression in human balding dermal papilla cells
I do believe that CS mentioned this study earlier (Preventable effect of L-threonate, an ascorbate metabolite, on androgen-driven balding via repression of dihydrotestosterone-induced dickkopf-1 expression in human hair dermal papilla cells), any updates on L-threonate?
http://www.ncbi.nlm.nih.gov/pubmed/21034532
L-ascorbic acid 2-phosphate represses the dihydrotestosterone-induced dickkopf-1 expression in human balding dermal papilla cells
Abstract
Recent studies suggested that dihydrotestosterone (DHT)-driven alteration in the autocrine and paracrine factors may be a key to androgen-potentiated balding. Also, we recently claimed that DHT-inducible dickkopf-1 (DKK-1) is one of the key factors involved in the androgen-potentiated balding. Here, we investigated whether L-ascorbic acid 2-phosphate (Asc 2-P), a derivative of L-ascorbic acid, could attenuate DHT-induced DKK-1 expression in dermal papilla cells (DPCs) from balding scalp. We observed that DHT-induced DKK-1 mRNA expression was attenuated in the presence of Asc 2-P as examined by RT-PCR analysis. In addition, we found that DHT-induced activation of luciferase reporter activity was significantly repressed when Asc 2-P was added together with DHT. Moreover, Asc 2-P repressed DHT-induced DKK-1 protein expression as examined by enzyme-linked immunosorbent assay (ELISA). Although there will be many hurdles to apply our finding to actual remedies, these results suggest that it would be worthy to evaluate Asc 2-P or its derivatives for the treatment and prevention of androgen-driven balding.
I do believe that CS mentioned this study earlier (Preventable effect of L-threonate, an ascorbate metabolite, on androgen-driven balding via repression of dihydrotestosterone-induced dickkopf-1 expression in human hair dermal papilla cells), any updates on L-threonate?
http://www.ncbi.nlm.nih.gov/pubmed/21034532
Misirlou- Posts : 1170
Join date : 2008-07-11
Re: L-ascorbic acid 2-phosphate represses dickkopf-1 expression
Misirlou - It turned out not to produce any noticeable effects. I gave it a solid 6-months try, and many others gave it a fair shot also. Nothing was reported.
It's possible that either the oral route was not effective, which was suggested by one member. The idea of a topical was expressed, but the delivery method was being discussed and that is where it was left.
It's possible that either the oral route was not effective, which was suggested by one member. The idea of a topical was expressed, but the delivery method was being discussed and that is where it was left.
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Re: L-ascorbic acid 2-phosphate represses dickkopf-1 expression
I see. Does this mean that Phytosphingosine 1-phosphate in it's current form is useless against hair loss?
Misirlou- Posts : 1170
Join date : 2008-07-11
Re: L-ascorbic acid 2-phosphate represses dickkopf-1 expression
Misirlou wrote:I see. Does this mean that Phytosphingosine 1-phosphate in it's current form is useless against hair loss?
I tried high-dose lecithin for a period of time, which contains Phosphatidic acid. I found no benefit that I could detect.
Also, others had tried the experiment also, with no results.
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Now available for consultation (hair and/or health)
http://www.immortalhair.org/health-consultation
Similar topics
» I-Ascorbic acid 2-phosphate represses the dihydrotestosterone-induced dickkopf-1 expression in human balding dermal papilla cells.
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» l-Ascorbic acid 2-phosphate
» I think this has been discussed before but why is ascorbic acid-2 phosphate not viable as a topical?
» L-Ascorbic acid 2-phosphate promotes elongation of hair shafts
» Its all interlinked
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