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The investigation of insulin resistance and metabolic syndrome in male patients with early-onset androgenetic alopecia
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The investigation of insulin resistance and metabolic syndrome in male patients with early-onset androgenetic alopecia
The investigation of insulin resistance and metabolic syndrome in male patients with early-onset androgenetic alopecia
Auteur(s) : Ceyda MUMCUOGLU, Tugba Rezan EKMEKCI, Sema UCAK
Résumé : Epidemiological studies have shown that diseases associated with insulin resistance and coronary artery disease are more frequently observed in men with androgenetic alopecia (AGA). We aimed to identify the presence of insulin resistance and metabolic syndrome in male patients with early-onset AGA. Fifty male patients (18-30 years) with AGA stage ≥ 3 (Hamilton-Norwood scale), body mass index <\; 27 and 40 weight- and age-matched male subjects were the study population. The weight, height, and waist circumference of all patients was measured. Levels of fasting glucose, insulin, and lipids were evaluated and oral glucose tolerance tests undertaken. Insulin resistance was analyzed through various indices and the presence of metabolic syndrome was assessed. Values of diastolic blood pressure and total cholesterol were significantly higher in the AGA group. Among insulin indices, only HOMA insulin resistance (HOMA-IR) and fasting insulin resistance index (FIRI) were higher in the AGA group. Given the criteria for metabolic syndrome, no significant differences were observed between the two groups. Although not supported by the other indices, high scores of HOMA-IR and FIRI suggest that male patients with early onset-AGA have insulin resistance. These data may raise awareness in susceptible individuals that lifestyle changes in the early period of life can reduce the risk of insulin resistance.
Auteur(s) : Ceyda MUMCUOGLU, Tugba Rezan EKMEKCI, Sema UCAK
Résumé : Epidemiological studies have shown that diseases associated with insulin resistance and coronary artery disease are more frequently observed in men with androgenetic alopecia (AGA). We aimed to identify the presence of insulin resistance and metabolic syndrome in male patients with early-onset AGA. Fifty male patients (18-30 years) with AGA stage ≥ 3 (Hamilton-Norwood scale), body mass index <\; 27 and 40 weight- and age-matched male subjects were the study population. The weight, height, and waist circumference of all patients was measured. Levels of fasting glucose, insulin, and lipids were evaluated and oral glucose tolerance tests undertaken. Insulin resistance was analyzed through various indices and the presence of metabolic syndrome was assessed. Values of diastolic blood pressure and total cholesterol were significantly higher in the AGA group. Among insulin indices, only HOMA insulin resistance (HOMA-IR) and fasting insulin resistance index (FIRI) were higher in the AGA group. Given the criteria for metabolic syndrome, no significant differences were observed between the two groups. Although not supported by the other indices, high scores of HOMA-IR and FIRI suggest that male patients with early onset-AGA have insulin resistance. These data may raise awareness in susceptible individuals that lifestyle changes in the early period of life can reduce the risk of insulin resistance.
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Re: The investigation of insulin resistance and metabolic syndrome in male patients with early-onset androgenetic alopecia
The more I read these studies the more I'm feel like I'm floating in the Bermuda Triangle of research papers.
The Ceyda MUMCUOGLU, Tugba Rezan EKMEKCI, Sema UCAK study on the one hand connects early onset AGA to insulin resistance later on in life while the study below links early onset AGA to decrease risk of prostate cancer. The same path to insulin resistance may lead to PC, but the MPB mechanism steps in or MPB is a by-product of something attempting to prevent PC.
Male pattern baldness and prostate cancer risk in a population-based case–control study
The Ceyda MUMCUOGLU, Tugba Rezan EKMEKCI, Sema UCAK study on the one hand connects early onset AGA to insulin resistance later on in life while the study below links early onset AGA to decrease risk of prostate cancer. The same path to insulin resistance may lead to PC, but the MPB mechanism steps in or MPB is a by-product of something attempting to prevent PC.
Male pattern baldness and prostate cancer risk in a population-based case–control study
Abstract
Purpose: Male pattern baldness (MPB) and prostate cancer (PCa) share commonality as prevalent, heritable and androgen-related conditions. Studies exploring the relationship between the two conditions have been inconclusive. Using a population-based, case–control study of PCa, we explore the relationship between early-onset MPB and PCa risk. Methods: Cases were men aged 35–74 diagnosed with PCa between 2002 and 2005 in King County, Washington. Controls were frequency matched by age and identified by random digit dialing. Hair pattern at age 30 and at 1 year prior to diagnosis (cases) or reference date (controls) was determined using showcards. PCa risk associated with balding was assessed with logistic regression. Results: Data from 999 cases of PCa and 942 controls were analyzed. Hair loss at age 30 was more common in controls (25.2%) than cases (19.8%, p = 0.005), and those with hair loss at age 30 had a 29% relative risk reduction for PCa (OR 0.71, 95% CI 0.56–0.91). No risk reduction was seen for men only reporting hair loss at referent age (OR 0.90, 95% CI 0.73–1.12). In men aged >60 at referent date, the risk reduction was greater for men with hair loss at age 30 from both the top of head and forehead (OR 0.55, 95% CI 0.33–0.93). Conclusion: Early-onset MPB was associated with a reduced relative risk of PCa in this population-based study. Further research into a possible mechanistic link between these prevalent and androgen-related conditions is warranted.
tonyj- Posts : 390
Join date : 2009-10-03
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