Angiogenin is expressed in human dermal papilla cells and stimulates hair growth

Arch Dermatol Res. 2008 Oct 21.

Angiogenin is expressed in human dermal papilla cells and stimulates hair growth.
Zhou N, Fan W, Li M.

Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Guangzhou Road 300, 210029, Nanjing, Jiangsu, China.

The perifollicular vasculature undergoes hair-cycle dependent expansion and degeneration. Multiple soluble factors derived from dermal papilla cells (DPCs) may act on surrounding blood vessels to influence angiogenesis, growth and differentiation, and thereby regulate cyclic hair growth. The goal of this study was to examine the expression of angiogenin, a potent angiogenic factor, in human DPCs, and to determine its role in hair growth. Reverse transcription polymerase chain reaction (RT-PCR), western blotting, immunofluorescence and ELISA analyzes were used to investigate the expression of angiogenin in human DPCs, while semi-quantitative RT-PCR was used to assess angiogenin mRNA expression in murine skin phased at different stages of the hair cycle. We detected angiogenin expression in DPCs, where it was found to be localized to the cytoplasm. Angiogenin mRNA was expressed in murine skin in a hair-cycle dependent manner, with maximum levels observed at the late anagen. Local injection of angiogenin promoted skin angiogenesis and induced anagen VI. In vitro studies showed that angiogenin significantly enhanced the elongation of hair follicles, and stimulated DPCs and ORS keratinocytes to proliferate. Taken together, these findings show that angiogenin is expressed in human DPCs, where it might contribute to hair growth directly, by stimulating DPCs and ORS keratinocytes to proliferate, or indirectly, by inducing local vascularization.

Hmm, interesting. Now, where to get our hands on this stuff...

nidhogge - I'm guessing, but can't confirm it, but think a laser helmet would probably increase angiogenin.

Really? Interesting, what gives that impression to you?

nidhogge - A device I am very familiar with called monochromatic infrared light therapy (anodyne) is a light emitting diode device with a different wave length than the laser helmets, but offer similar effects. One of them is increasing angiogenesis. The device is used to heal necrotic tissue, ulcers, wounds that do not heal properly due to low immunity and tissue hypoxia.