Is fish bad for you.

Please give me recent studies that show wild fish like salmon and mahi tuna are bad for you. fish with gills to filter out all the junk.

vitalchoice.com best fish you can buy

I don't think fish is bad for you o.O

I think most people believe that most fish is astoundingly good for you unless it is full of toxins.. this is still something that I am learning about though

Mercury in Fish? Don't worry about it!

http://www.immortalhair.org/apps/blog/show/2871209-mercury-in-fish-don-t-worry-about-it-


Quoting from Robert Ferguson: "In Japan, 87 percent of the population exceeds the EPA (mercury levels). In Hong Kong, Chinese children have mean mercury hair levels (almost twice those of the EPA limits). These children, like those of every high fish-consuming nation, seriously out perform U.S. children from grades 4-12 on international standardized tests for math and science. One key reason could be because they eat lots of fish!"

Ferguson said: "Study after study shows no adverse effects on children from maternal fish consumption as high as 12-14 meals per week. Only benefits have been reported, such as superior eyesight, higher child mental development scores, less hyperactivity, good heart and brain function and improved intelligence at 4 years of age."


In practice, selenium and mercury exist in different forms. Not all selenium forms might work for every form of Mercury. One should avoid man made Mercury compounds like the plague... the sources are many.

Mercury in fish flesh sure doesn't help, also think about all the pollution in the sea, all the crude oil that has spilled out into the seas and all the garbage floating around out there!

The main problem with fish is the acidic-animal-protein. Once again, animal-protein decreases IGFBP: leaving "free" IGF-1 to float around in the serum. "Free" IGF-1 decreases SHBG, which causes an excess of testosterone to float around "free" in the blood stream (lowering your total testosterone levels). Only "free" testosterone can convert into estrogen or DHT. Once converted into estrogen or DHT, it is then bound to SHBG and transported to the SHBG-receptor located in the sebaceous glands. Once SHBG binds to its receptor it synthesizes IGF-1 within that tissue, as a result the sebaceous gland enlarges and produces excess sebum. The excess sebum then clog’s the hair follicle. A bacterium eats the sebum and the immune system picks up on this bacteria and tries to attack it. The way it attacks it is with an autoimmune response called inflammation. It is the inflammation that causes the hair to fall out, and it is the clogged pore, which prevents its regrowth.

MisterE, so if what you're saying about SHBG is true then something like nettle root, which frees up testosterone by decreasing SHBG would actually increase estrogen and be bad for our hair?

And if we aim to increase testosterone as much as we can naturally while normalizing SHBG will we be able to build more muscle than we would have if we aimed to up free T? Because I always thought that bound T was basically rendered useless.

If you want SCIENCE BACKED information on reducing sebum production (acne, dandruff) read Dr. Loren Cordain's book, the dietary cure for acne. It explains how IGF-1 can rise too much... NOT due to fat or protein, but due to grains, lectins and other things.

Yanks wrote:MisterE, so if what you're saying about SHBG is true then something like nettle root, which frees up testosterone by decreasing SHBG would actually increase estrogen and be bad for our hair?

And if we aim to increase testosterone as much as we can naturally while normalizing SHBG will we be able to build more muscle than we would have if we aimed to up free T? Because I always thought that bound T was basically rendered useless.

That's something I have been wondering about, as well. I am currently using Nettle Root extract and will continue because it has done wonders for my libido. But what's interesting is that since taking it, if I take Deer Antler Velvet (igf-1), or a potent aromatase inhibitor, my skin gets very oily, like I used to respond to such supps in my twenties. So I can see how lower SHBG can lead to more DHT. But for me, the shift seems to have been healthy--I just have to steer clear of things I used to take to boost androgens.

misterE wrote:Mercury in fish flesh sure doesn't help, also think about all the pollution in the sea, all the crude oil that has spilled out into the seas and all the garbage floating around out there!

The main problem with fish is the acidic-animal-protein. Once again, animal-protein decreases IGFBP: leaving "free" IGF-1 to float around in the serum. "Free" IGF-1 decreases SHBG, which causes an excess of testosterone to float around "free" in the blood stream (lowering your total testosterone levels). Only "free" testosterone can convert into estrogen or DHT. Once converted into estrogen or DHT, it is then bound to SHBG and transported to the SHBG-receptor located in the sebaceous glands. Once SHBG binds to its receptor it synthesizes IGF-1 within that tissue, as a result the sebaceous gland enlarges and produces excess sebum. The excess sebum then clog’s the hair follicle. A bacterium eats the sebum and the immune system picks up on this bacteria and tries to attack it. The way it attacks it is with an autoimmune response called inflammation. It is the inflammation that causes the hair to fall out, and it is the clogged pore, which prevents its regrowth.

mister e: Is it only SHBG that has been bound with DHT or estrogen that binds to the SHBG receptor and then causes the excess sebum and inflammation, or does SHBG bound with testosterone also bind to the SHBG receptor and cause this issue too? Is your vegan type diet the primary method you use to ensure minimal levels of DHT and estrogen? Is there other key things that you would recommend beyond diet to accomplish this?

Yanks wrote:MisterE, so if what you're saying about SHBG is true then something like nettle root, which frees up testosterone by decreasing SHBG would actually increase estrogen and be bad for our hair?

And if we aim to increase testosterone as much as we can naturally while normalizing SHBG will we be able to build more muscle than we would have if we aimed to up free T? Because I always thought that bound T was basically rendered useless.

Nettle root displaces DHT from SHBG or in other words nettle root increases free-DHT, which is good… because only free-DHT can be excreted out of the body.

Lignans interfering with 5 alpha-dihydrotestosterone binding to human sex hormone-binding globulin.Schöttner M, Spiteller G, Gansser D.
Lehrstuhl für organische Chemie, Universität Bayreuth, Germany.

The natural lignans (-)-3,4-divanillyltetrahydrofuran (1), (-)-matairesinol (2), (-)-secoisolariciresinol (3), (+/-)-enterolactone (4), (+/-)-enterodiol (5), and nordihydroguaiaretic acid (NDGA) (6) reduce the binding of 3H-labeled 5 alpha-dihydrotestosterone (DHT) to human sex hormone-binding globulin (SHBG). (-)-3,4-Divanillyltetrahydrofuran (1) has the highest binding affinity (Ka = 3.2 +/- 1.7 x 10(6)M-1) of all lignans investigated so far; the reversibility of its binding and a double reciprocal plot suggest a competitive inhibition of the SHBG-DHT interaction. Increasing hydrophobity in the aliphatic part of the lignans (butane-1,4-diol-butanolide-tetrahydrofuran structures) leads to higher binding affinity. In the aromatic part, a 3-methoxy-4-hydroxy substitution pattern is most effective for binding to SHBG.

PMID: 9461660

johnt wrote:
mister e: Is it only SHBG that has been bound with DHT or estrogen that binds to the SHBG receptor and then causes the excess sebum and inflammation, or does SHBG bound with testosterone also bind to the SHBG receptor and cause this issue too?

Testosterone is only active in muscles and I believe bone as well. So SHBG would bind testosterone to either muscle or bone tissues only. DHT and estrogen are active in other tissues such as the skin or brain.

johnt wrote:
Is your vegan type diet the primary method you use to ensure minimal levels of DHT and estrogen?

Yes the (low-fat/high-fiber) vegan diet is the best way to balance hormones; keeping IGF-1, estrogen and DHT low and SHBG-bound-testosterone high [1].

johnt wrote:
Is there other key things that you would recommend beyond diet to accomplish this?

Drink nothing but water, unsweet teas, and dark-red-wine and do intense cardiovascular exercises like running every day.

[1] Hormones and diet: low insulin-like growth factor 1but normal bioavailable androgens in vegan men.

misterE wrote:

Yanks wrote:MisterE, so if what you're saying about SHBG is true then something like nettle root, which frees up testosterone by decreasing SHBG would actually increase estrogen and be bad for our hair?

And if we aim to increase testosterone as much as we can naturally while normalizing SHBG will we be able to build more muscle than we would have if we aimed to up free T? Because I always thought that bound T was basically rendered useless.

Nettle root displaces DHT from SHBG or in other words nettle root increases free-DHT, which is good… because only free-DHT can be excreted out of the body.

Lignans interfering with 5 alpha-dihydrotestosterone binding to human sex hormone-binding globulin.Schöttner M, Spiteller G, Gansser D.
Lehrstuhl für organische Chemie, Universität Bayreuth, Germany.

The natural lignans (-)-3,4-divanillyltetrahydrofuran (1), (-)-matairesinol (2), (-)-secoisolariciresinol (3), (+/-)-enterolactone (4), (+/-)-enterodiol (5), and nordihydroguaiaretic acid (NDGA) (6) reduce the binding of 3H-labeled 5 alpha-dihydrotestosterone (DHT) to human sex hormone-binding globulin (SHBG). (-)-3,4-Divanillyltetrahydrofuran (1) has the highest binding affinity (Ka = 3.2 +/- 1.7 x 10(6)M-1) of all lignans investigated so far; the reversibility of its binding and a double reciprocal plot suggest a competitive inhibition of the SHBG-DHT interaction. Increasing hydrophobity in the aliphatic part of the lignans (butane-1,4-diol-butanolide-tetrahydrofuran structures) leads to higher binding affinity. In the aromatic part, a 3-methoxy-4-hydroxy substitution pattern is most effective for binding to SHBG.

PMID: 9461660

Thanks. I've found your posts to be quite helpful.

misterE wrote:Mercury in fish flesh sure doesn't help, also think about all the pollution in the sea, all the crude oil that has spilled out into the seas and all the garbage floating around out there!
[

Mercury in the sea ? Again typical mainstream nonsense, isnt mercury natural element? Dont you think that the life in the sea and the oceans adapted to natural levels of mercury, lead or cadmium? The mass of water in oceans is so huge that there cant be higher levels of mercury from human activity except near the polluted river entries. If man wants to buy nonpolluted fish must look at FAO.
Crude oil? o my God its actual ,isnt it? ti seems to me that you cant eat any vegies or fruits or grains from oil polluted fields, except those hoed by hand

I second mickey.

What is FOA.

to xyztrace
FAO is fishing area. it should be mentioned on the package. http://www.fao.org/fishery/area/search/en

misterE wrote:

Yanks wrote:MisterE, so if what you're saying about SHBG is true then something like nettle root, which frees up testosterone by decreasing SHBG would actually increase estrogen and be bad for our hair?

And if we aim to increase testosterone as much as we can naturally while normalizing SHBG will we be able to build more muscle than we would have if we aimed to up free T? Because I always thought that bound T was basically rendered useless.

Nettle root displaces DHT from SHBG or in other words nettle root increases free-DHT, which is good… because only free-DHT can be excreted out of the body.

Lignans interfering with 5 alpha-dihydrotestosterone binding to human sex hormone-binding globulin.Schöttner M, Spiteller G, Gansser D.
Lehrstuhl für organische Chemie, Universität Bayreuth, Germany.

The natural lignans (-)-3,4-divanillyltetrahydrofuran (1), (-)-matairesinol (2), (-)-secoisolariciresinol (3), (+/-)-enterolactone (4), (+/-)-enterodiol (5), and nordihydroguaiaretic acid (NDGA) (6) reduce the binding of 3H-labeled 5 alpha-dihydrotestosterone (DHT) to human sex hormone-binding globulin (SHBG). (-)-3,4-Divanillyltetrahydrofuran (1) has the highest binding affinity (Ka = 3.2 +/- 1.7 x 10(6)M-1) of all lignans investigated so far; the reversibility of its binding and a double reciprocal plot suggest a competitive inhibition of the SHBG-DHT interaction. Increasing hydrophobity in the aliphatic part of the lignans (butane-1,4-diol-butanolide-tetrahydrofuran structures) leads to higher binding affinity. In the aromatic part, a 3-methoxy-4-hydroxy substitution pattern is most effective for binding to SHBG.

PMID: 9461660

So SHBG bound DHT is worse for our hair? Do you think high SHBG is good or bad for hair?

The observational studies I remember between balding and non-balding types showed two big hormonal differences: lower SHBG and lower testosterone for the balding group. DHT levels were roughly the same between groups. If balding really is due to hormonal differences caused by diet, as your hypothesis says, then how does this mesh with the hormonal studies between groups?

misterE wrote:

Yanks wrote:MisterE, so if what you're saying about SHBG is true then something like nettle root, which frees up testosterone by decreasing SHBG would actually increase estrogen and be bad for our hair?

And if we aim to increase testosterone as much as we can naturally while normalizing SHBG will we be able to build more muscle than we would have if we aimed to up free T? Because I always thought that bound T was basically rendered useless.

Nettle root displaces DHT from SHBG or in other words nettle root increases free-DHT, which is good… because only free-DHT can be excreted out of the body.

Lignans interfering with 5 alpha-dihydrotestosterone binding to human sex hormone-binding globulin.Schöttner M, Spiteller G, Gansser D.
Lehrstuhl für organische Chemie, Universität Bayreuth, Germany.

The natural lignans (-)-3,4-divanillyltetrahydrofuran (1), (-)-matairesinol (2), (-)-secoisolariciresinol (3), (+/-)-enterolactone (4), (+/-)-enterodiol (5), and nordihydroguaiaretic acid (NDGA) (6) reduce the binding of 3H-labeled 5 alpha-dihydrotestosterone (DHT) to human sex hormone-binding globulin (SHBG). (-)-3,4-Divanillyltetrahydrofuran (1) has the highest binding affinity (Ka = 3.2 +/- 1.7 x 10(6)M-1) of all lignans investigated so far; the reversibility of its binding and a double reciprocal plot suggest a competitive inhibition of the SHBG-DHT interaction. Increasing hydrophobity in the aliphatic part of the lignans (butane-1,4-diol-butanolide-tetrahydrofuran structures) leads to higher binding affinity. In the aromatic part, a 3-methoxy-4-hydroxy substitution pattern is most effective for binding to SHBG.

PMID: 9461660

So, regarding nettle root, is this true for estrogen as well? And I'm more worried about testosterone. I always thought free T was was useful to our muscles/bones/heart health etc.

Are you saying that if we free up T with nettle then it will be excreted or converted to DHT or estrogen (even though DHT will be excreted too so I assume levels wouldn't rise)?

Sorry, but I'm kinda confused here.

A lot of this stuff posted by misterE is flat out wrong, related to SHBG, nettle, etc.

There is absolutely no evidence that nettle would lower SHBG in young men who have low SHBG levels.

It is highly unlikely for this to occur, because nettle is antihyperglycemic in action, meaning that it promotes better insulin levels.

These studies involve hypertrophic prostates, not a condition that is conducive to younger men.

Low SHBG is an iodine/thyroid or blood sugar problem. It is normalized with better diet or improved thyroid function.

For most men, SHBG is too high, not too low.

albe wrote:

So SHBG bound DHT is worse for our hair? Do you think high SHBG is good or bad for hair?

Well, if you have high SHBG, you are going to have high SHBG-bound-testosterone, which cannot convert into DHT (or estrogen), which is exactly what you want. Nettle root is shown to increase free-DHT by displacing DHT from SHBG, thus lowering the total DHT level. Nettle doesn't lower SHBG… it just occupies it. But, as SHBG increases so does SHBG-bound-estradiol (which mimics the effects of DHT [1]) but estradiol (and other estrogens) has a low binding affinity to SHBG and can easily be displaced with foods rich in phytoestrogens, which are all plant-based foods.

albe wrote:

If balding really is due to hormonal differences caused by diet, as your hypothesis says, then how does this mesh with the hormonal studies between groups?

Eating large amounts of fat, animal-protein or consuming dairy products causes a massive increase in free-IGF-1, which then decreases SHBG [2] [3] [4] [5] [6] [7].







[1] Estradiol Activates the Prostate Androgen Receptor and Prostate-specific Antigen Secretion through the Intermediacy of Sex Hormone-binding Globulin.

[2] Diet and Sex Hormone-Binding Globulin.

[3] Animal protein intake, serum insulin-like growth factor I, and growth in healthy 2.5-y-old Danish children.

[4] Dietary correlates of plasma insulin-like growth factor I and insulin-like growth factor binding protein 3 concentrations.

[5] Are diet–prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-I and IGFBP-3 in healthy middle-aged men.

[6] Milk intake, circulating levels of insulin-like growth factor-I, and risk of colorectal cancer in men.

[7] Long-term low-protein, low-calorie diet and endurance exercise modulate metabolic factors associated with cancer risk.

Yanks wrote:
So, regarding nettle root, is this true for estrogen as well? And I'm more worried about testosterone. I always thought free T was was useful to our muscles/bones/heart health etc.

Yes, the lignans in nettle root could displace estrogen from SHBG, but I haven't seen evidence of this, I've only seen evidence that nettle root displaces DHT from SHBG, thus increasing its metabolic clearance.

Free-testosterone is a prohormone; a hormone that is used by the body to create other hormones. SHBG role in the body is to bind testosterone and transport it to the SHBG-receptor, keeping it safe from converting away and keeping it from being excreted from the body in the urine or feces. Anything that increases free-testosterone is going to lower the total amount of testosterone (SHBG-bound-testosterone). So you want to have free-DHT and free-estrogen (because these will be excreted) but you want your testosterone to be safely bound to SHBG, that way it doesn't get converted or excreted. The best way to do that is with a low-fat/high-fiber carbohydrate based vegan diet, because vegans are shown to have much higher SHBG-bound-testosterone compared to omnivores [1].





[1] Hormones and diet: low insulin-like growth factor-I but normal bioavailable androgens in vegan men.

The main problem with fish is the acidic-animal-protein. Once again, animal-protein decreases IGFBP: leaving "free" IGF-1 to float around in the serum. "Free" IGF-1 decreases SHBG

I eat 1lb of beef a day, 7 eggs a day, 1 glass of raw milk, my SHBG has been increasing.

my igf1, igfbp, DHT leves are near perect also

CausticSymmetry wrote:

For most men, SHBG is too high, not too low.

Really? I thought insulin and IGF-1 lowered SHBG, not increase it!

May be you are not human blackjack and me too My SHGB levels are higher too after my high meat and high fat diet so Free T, DHT is lower, estradiol lower too. Cholesterol in normal levels despite I eat many butter and eggs.