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Oxidative stress and senescence in the pathology of AGA.
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Oxidative stress and senescence in the pathology of AGA.
Just a thread for me to put stuff on oxidative stress, senescence, ROS, catalase, procyanidins, etc.
I often wish I had a time machine so I could go back and implement a comprehensive cellular longevity protocol along with everything else i've done over the years to see if it would have made a difference in where I stand today. I like to think it would have... a lot of fingers are pointing at loss of cellular function as being a signifigant player in the pathology of AGA.
Check out this link. Pretty awesome from what I've read of it so far:
http://ajpregu.physiology.org/cgi/reprint/00327.2006v1.pdf
I often wish I had a time machine so I could go back and implement a comprehensive cellular longevity protocol along with everything else i've done over the years to see if it would have made a difference in where I stand today. I like to think it would have... a lot of fingers are pointing at loss of cellular function as being a signifigant player in the pathology of AGA.
Check out this link. Pretty awesome from what I've read of it so far:
http://ajpregu.physiology.org/cgi/reprint/00327.2006v1.pdf
chore- Posts : 34
Join date : 2009-06-21
Re: Oxidative stress and senescence in the pathology of AGA.
Interesting... p53 appears essential in chemotherapy-induced hair loss. Radiation, which also produces hair loss, is a known ROS-generating stressor... oxidative stress can trigger senescence... p53 is expressed by cells senescent cells and when inhibitors of p53 are introduced, senescent cells resume proliferation. I have to wonder if non-balding follicles found in cancer patients are able to balance back out the spike in p53 that accompanied their anti-cancer treatment explaining why they can regrow hair where maybe AGA follicles can't overcome p53? Maybe the oxidative stress is keeping the p53 levels elevated and that's what is keeping our cells in senescence?
http://en.scientificcommons.org/22644151
http://cancerres.aacrjournals.org/cgi/content/full/60/18/5002
http://ajpregu.physiology.org/cgi/reprint/00327.2006v1.pdf
http://en.scientificcommons.org/22644151
http://cancerres.aacrjournals.org/cgi/content/full/60/18/5002
http://ajpregu.physiology.org/cgi/reprint/00327.2006v1.pdf
chore- Posts : 34
Join date : 2009-06-21
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