Polydeoxyribonucleotide(PDRN)

MikeGore Wed Mar 01, 2023 8:53 pm

Have you heard of Polydeoxyribonucleotide(PDRN)? What are your thoughts on this and could it be a useful tool in our fight against hair loss?

MikeGore Thu Mar 23, 2023 10:20 am

If wnt signalling is improved, can slick bald areas regrow hair? Can PDRN injections help with that?

"Nuclear factor-κB (NF-κB) plays a central role in psoriasis and canonical Wnt/β-catenin pathway blunts the immune-mediated inflammatory cascade in psoriasis. Adenosine A2A receptor activation blocks NF-κB and boosts the Wnt/β-catenin signaling. PDRN (Polydeoxyribonucleotide) is a biologic agonist of the A2A receptor and its effects were studied in an experimental model of psoriasis. Psoriasis-like lesions were induced by a daily application of imiquimod (IMQ) on the shaved back skin of mice for 7 days. Animals were randomly assigned to the following groups: Sham psoriasis challenged with Vaseline; IMQ animals challenged with imiquimod; and IMQ animals treated with PDRN (8 mg/kg/ip). An additional arm of IMQ animals was treated with PDRN plus istradefylline (KW6002; 25 mg/kg/ip) as an A2A antagonist. PDRN restored a normal skin architecture, whereas istradefylline abrogated PDRN positive effects, thus pointing out the mechanistic role of the A2A receptor. PDRN decreased pro-inflammatory cytokines, prompted Wnt signaling, reduced IL-2 and increased IL-10. PDRN also reverted the LPS repressed Wnt-1/β-catenin in human keratinocytes and these effects were abolished by ZM241385, an A2A receptor antagonist. Finally, PDRN reduced CD3+ cells in superficial psoriatic dermis. PDRN anti-psoriasis potential may be linked to a “dual mode” of action: NF-κB inhibition and Wnt/β-catenin stimulation."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072802/

Polydeoxyribonucleotide(PDRN)

Polydeoxyribonucleotide(PDRN)

Re: Polydeoxyribonucleotide(PDRN)