Hair-growth promoting effect and anti-inflammatory mechanism of Ginkgo biloba polysaccharides

Carbohydr Polym. 2022 Feb 15;278:118811. doi: 10.1016/j.carbpol.2021.118811. Epub 2021 Oct 26.
Hair-growth promoting effect and anti-inflammatory mechanism of Ginkgo biloba polysaccharides
Yingna Li 1, Yu Sheng 2, Jiuyue Liu 2, Guangyu Xu 2, Wanwen Yu 3, Qingwen Cui 2, Xuechun Lu 2, Peige Du 4, Liping An 5

The aim of this study was to optimize the separation and purification technology of water-soluble Ginkgo biloba leaves polysaccharides (WGBP), analyze its composition characteristics, observe its hair-growth promoting effect in alopecia areata mice, clarify the polysaccharide fraction with bioactive activities, and explore its anti-inflammation mechanism. We isolated acidic polysaccharides (WGBP-A2) and purified a RG-I type polysaccharide (WGBP-A2b) with a molecular weight of 44 kDa. Results showed that WGBP-A2 could significantly increase the contents of VEGF and HGF in the skin tissue of alopecia areata mice, decrease the contents of Inflammatory factors in the serum.

On a cellular level, the expressions of p-p65 and p-IκBα, TNF-α and IL-1β in HUVECs treated with WGBP-A2b were down-regulated. The bioinformatic analysis showed that the inflammation signaling pathway was significantly changed. Its specific mechanism may be related to its regulating the expression of p-p65 p-IκBα, TNF-α and IL-1β proteins in the inflammation signaling pathway.

Keywords: Alopecia areata; Ginkgo biloba polysaccharides; HUVECs; Inflammation; RNA-seq.

I perhaps should start taking more of my neglected bottle of this. I'm not familiar with all the terms, It says alopecia areata will it help with androgenic alopecia as well?