Search
Check Out Our Sponsors
Latest topics
Growth Hormone and the Human Hair Follicle
Page 1 of 1
Growth Hormone and the Human Hair Follicle
Int J Mol Sci. 2021 Dec 8;22(24):13205. doi: 10.3390/ijms222413205.
Growth Hormone and the Human Hair Follicle
Elijah J Horesh 1, Jérémy Chéret 1, Ralf Paus 1 2 3
Ever since the discoveries that human hair follicles (HFs) display the functional peripheral equivalent of the hypothalamic-pituitary-adrenal axis, exhibit elements of the hypothalamic-pituitary-thyroid axis, and even generate melatonin and prolactin, human hair research has proven to be a treasure chest for the exploration of neurohormone functions. However, growth hormone (GH), one of the dominant neurohormones of human neuroendocrine physiology, remains to be fully explored in this context. This is interesting since it has long been appreciated clinically that excessive GH serum levels induce distinct human skin pathology. Acromegaly, or GH excess, is associated with hypertrichosis, excessive androgen-independent growth of body hair, and hirsutism in females, while dysfunctional GH receptor-mediated signaling (Laron syndrome) is associated with alopecia and prominent HF defects. The outer root sheath keratinocytes have recently been shown to express functional GH receptors. Furthermore, and contrary to its name, recombinant human GH is known to inhibit female human scalp HFs' growth ex vivo, likely via stimulating the expression of the catagen-inducing growth factor, TGF-β2. These limited available data encourage one to systematically explore the largely uncharted role of GH in human HF biology to uncover nonclassical functions of this core neurohormone in human skin physiology.
Keywords: growth hormone; hair follicle; insulin-like growth factor-1; somatotropic axis.
Full Text
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706217/
Growth Hormone and the Human Hair Follicle
Elijah J Horesh 1, Jérémy Chéret 1, Ralf Paus 1 2 3
Ever since the discoveries that human hair follicles (HFs) display the functional peripheral equivalent of the hypothalamic-pituitary-adrenal axis, exhibit elements of the hypothalamic-pituitary-thyroid axis, and even generate melatonin and prolactin, human hair research has proven to be a treasure chest for the exploration of neurohormone functions. However, growth hormone (GH), one of the dominant neurohormones of human neuroendocrine physiology, remains to be fully explored in this context. This is interesting since it has long been appreciated clinically that excessive GH serum levels induce distinct human skin pathology. Acromegaly, or GH excess, is associated with hypertrichosis, excessive androgen-independent growth of body hair, and hirsutism in females, while dysfunctional GH receptor-mediated signaling (Laron syndrome) is associated with alopecia and prominent HF defects. The outer root sheath keratinocytes have recently been shown to express functional GH receptors. Furthermore, and contrary to its name, recombinant human GH is known to inhibit female human scalp HFs' growth ex vivo, likely via stimulating the expression of the catagen-inducing growth factor, TGF-β2. These limited available data encourage one to systematically explore the largely uncharted role of GH in human HF biology to uncover nonclassical functions of this core neurohormone in human skin physiology.
Keywords: growth hormone; hair follicle; insulin-like growth factor-1; somatotropic axis.
Full Text
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706217/
_________________
My regimen
http://www.immortalhair.org/mpb-regimen
Now available for consultation (hair and/or health)
http://www.immortalhair.org/health-consultation
Similar topics
» Growth Hormone and the Human Hair Follicle
» Growth Hormone and the Human Hair Follicle
» Functions of exogenous application of connective tissue growth factor in stimulating human dermal papilla cells and human hair follicle outer root sheath cells for reconstructive tissue-engineering hair follicles
» Human Growth Hormone affect on hair? New product...
» Hair Growth Promoting Effect of Hottuynia cordata Extract in Cultured Human Hair Follicle Dermal Papilla Cells.
» Growth Hormone and the Human Hair Follicle
» Functions of exogenous application of connective tissue growth factor in stimulating human dermal papilla cells and human hair follicle outer root sheath cells for reconstructive tissue-engineering hair follicles
» Human Growth Hormone affect on hair? New product...
» Hair Growth Promoting Effect of Hottuynia cordata Extract in Cultured Human Hair Follicle Dermal Papilla Cells.
Page 1 of 1
Permissions in this forum:
You cannot reply to topics in this forum
|
|
Today at 11:54 am by CausticSymmetry
» China is at it again
Today at 10:05 am by shaftless
» Ways to increase adult stem cells
Today at 1:40 am by el_llama
» pentadecanoic acid
Sat May 04, 2024 6:56 pm by CausticSymmetry
» Exosome Theory and Herpes
Thu May 02, 2024 11:25 am by CausticSymmetry
» Road to recovery - my own log of everything I'm currently trying for HL
Mon Apr 29, 2024 9:55 pm by JtheDreamer
» Medical Coder During C0NV!D
Sat Apr 27, 2024 12:00 am by CausticSymmetry
» Potential Natural Products Regulation of Molecular Signaling Pathway in Dermal Papilla Stem Cells
Tue Apr 16, 2024 3:44 pm by CausticSymmetry
» Breast Biopsy
Sat Apr 13, 2024 10:23 am by shaftless