Effect of a sphingolipid-mimetic compound on the promotion of hair growth: A randomized, double-blind, placebo-controlled clinical trial

J Cosmet Dermatol
. 2020 Jul;19(7):1715-1722. doi: 10.1111/jocd.13220. Epub 2019 Nov 19.
Effect of a sphingolipid-mimetic compound on the promotion of hair growth: A randomized, double-blind, placebo-controlled clinical trial
Weon Ju Lee 1, Chihyeon Sohng 1, Jun Young Kim 1, Kyung Duck Park 1, Yong Hyun Jang 1, Seok-Jong Lee 1
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Background: Pattern hair loss is a very common skin disorder, but more therapeutic modalities for hair growth are still required.

Objective: We investigated the effect of a newly synthesized sphingolipid-mimetic compound (pseudo-ceramide: bis-oleamide isopropyl alcohol [BOI]) on the promotion of hair growth for patients with mild pattern hair loss.

Methods: A total of 58 patients with mild pattern hair loss participated in this clinical trial. A randomized, double-blind, placebo-controlled clinical trial was conducted for 6 months. Participants in the experimental group applied 1% BOI lotion (ceramide HS) on the whole scalp once a day for 6 months. Participants in the control group applied simulacrum using the same protocol. We evaluated daily hair loss, hair density, hair thickness, and hair length at intervals of 3 months; patient satisfaction and adverse events were evaluated at 6 months.

Results: At 6 months in the experimental group, daily hair loss at baseline (52.52 ± 33.98) decreased to 40.41 ± 24.78, vertex hair density at baseline (131.07 ± 43.73) increased to 156.00 ± 39.59, frontal hair density at baseline (104.21 ± 30.72) increased to 124.10 ± 28.28, thickness of vertex hair at baseline (0.067 ± 0.012 cm) increased to 0.075 ± 0.014 cm, thickness of frontal hair at baseline (0.070 ± 0.009 cm) increased to 0.076 ± 0.012 cm, and hair growth rate was 16.17 ± 1.89 mm/month.

Conclusion: Ceramide HS may be a new candidate for the treatment of pattern hair loss.

Keywords: ceramide; hair; pattern hair loss; shampoo; sphingolipid.

https://onlinelibrary.wiley.com/doi/abs/10.1111/jocd.13220

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