Molecular Mechanisms of Hair Growth and Regeneration: Current Understanding and Novel Paradigms.

Dermatology. 2020 Mar 12:1-10. doi: 10.1159/000506155. [Epub ahead of print]
Molecular Mechanisms of Hair Growth and Regeneration: Current Understanding and Novel Paradigms.
Houschyar KS1, Borrelli MR2, Tapking C3,4, Popp D3,5, Puladi B6, Ooms M6, Chelliah MP2, Rein S7, Pförringer D8, Thor D9, Reumuth G10, Wallner C1, Branski LK3, Siemers F10, Grieb G11, Lehnhardt M1, Yazdi AS12, Maan ZN2, Duscher D13.

Hair is a defining feature of mammals and has critical functions, including protection, production of sebum, apocrine sweat and pheromones, social and sexual interactions, thermoregulation, and provision of stem cells for skin homeostasis, regeneration, and repair. The hair follicle (HF) is considered a "mini-organ," consisting of intricate and well-organized structures which originate from HF stem and progenitor cells. Dermal papilla cells are the main components of the mesenchymal compartments in the hair bulb and are instrumental in generating signals to regulate the behavior of neighboring epithelial cells during the hair cycle. Mesenchymal-epithelial interactions within the dermal papilla niche drive HF embryonic development as well as the postnatal hair growth and regeneration cycle. This review summarizes the current understanding of HF development, repair, and regeneration, with special focus on cell signaling pathways governing these processes. In particular, we discuss emerging paradigms of molecular signaling governing the dermal papilla-epithelial cellular interactions during hair growth and maintenance and the recent progress made towards tissue engineering of human hair follicles.

KEYWORDS:
Follicle; Hair growth; Hypoxia-inducible factor pathway; Regeneration; Stem cells; Wnt; β-Catenin

Keep in mind this is a commercial study (conflict of interest), however it's a good summary of some of the mechanisms.

https://www.karger.com/Article/FullText/506155

CausticSymmetry wrote:Dermatology. 2020 Mar 12:1-10. doi: 10.1159/000506155. [Epub ahead of print]
Molecular Mechanisms of Hair Growth and Regeneration: Current Understanding and Novel Paradigms.
Houschyar KS1, Borrelli MR2, Tapking C3,4, Popp D3,5, Puladi B6, Ooms M6, Chelliah MP2, Rein S7, Pförringer D8, Thor D9, Reumuth G10, Wallner C1, Branski LK3, Siemers F10, Grieb G11, Lehnhardt M1, Yazdi AS12, Maan ZN2, Duscher D13.

Hair is a defining feature of mammals and has critical functions, including protection, production of sebum, apocrine sweat and pheromones, social and sexual interactions, thermoregulation, and provision of stem cells for skin homeostasis, regeneration, and repair. The hair follicle (HF) is considered a "mini-organ," consisting of intricate and well-organized structures which originate from HF stem and progenitor cells. Dermal papilla cells are the main components of the mesenchymal compartments in the hair bulb and are instrumental in generating signals to regulate the behavior of neighboring epithelial cells during the hair cycle. Mesenchymal-epithelial interactions within the dermal papilla niche drive HF embryonic development as well as the postnatal hair growth and regeneration cycle. This review summarizes the current understanding of HF development, repair, and regeneration, with special focus on cell signaling pathways governing these processes. In particular, we discuss emerging paradigms of molecular signaling governing the dermal papilla-epithelial cellular interactions during hair growth and maintenance and the recent progress made towards tissue engineering of human hair follicles.

KEYWORDS:
Follicle; Hair growth; Hypoxia-inducible factor pathway; Regeneration; Stem cells; Wnt; β-Catenin

Keep in mind this is a commercial study (conflict of interest), however it's a good summary of some of the mechanisms.

https://www.karger.com/Article/FullText/506155

CS, do you have your perfered list of HIF upregulators?

one is Vitamin C, in any ascorbate you can imagine.

One area of concern about Hypoxia-inducible factor pathway is that anything that controls it in a natural way, will act as more of a biological response modifier or regulating it under certain conditions.

If there were a drug to switch this on, it would probably lead to cancer. This is why some hair growth drugs never passed through initial phase I clinical trials.

Also, many pro-hair growth botanicals often tone down the HIF pathway, to prevent blood vessel growth under cancerous conditions.

Things like Arginine should help improve HIF pathway.