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Association between TAP1 gene polymorphisms and alopecia areata in a Korean population
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Association between TAP1 gene polymorphisms and alopecia areata in a Korean population
CausticSymmetry Thu Jan 21, 2016 3:43 am
Genet Mol Res. 2015 Dec 29;14(4):18820-7. doi: 10.4238/2015.December.28.31.
Association between TAP1 gene polymorphisms and alopecia areata in a Korean population.
Kim HK1, Lee H1, Lew BL2, Sim WY2, Kim YO3, Lee SW3, Lee S4, Cho IK5, Kwon JT1, Kim HJ1,6.
The transporter 1 ATP-binding cassette sub-family B (MDR/TAP) gene (TAP1) is located in the major histocompatibility complex class II region, and forms a heterodimer that plays a key role in endogenous antigen presentation pathways. Investigation of polymorphisms identified in these loci has revealed an association with several autoimmune disorders. Alopecia areata (AA) is a common autoimmune disease resulting from T cell-induced damage to hair follicles. The present study documents for the first time a comparison between the allelic and genotypic frequencies of TAP1 single nucleotide polymorphisms (SNPs) in patients with AA and those of a control group, using a direct sequencing method. Our results suggest an association between a promoter SNP (rs2071480) and susceptibility to this disease.
Association between TAP1 gene polymorphisms and alopecia areata in a Korean population.
Kim HK1, Lee H1, Lew BL2, Sim WY2, Kim YO3, Lee SW3, Lee S4, Cho IK5, Kwon JT1, Kim HJ1,6.
The transporter 1 ATP-binding cassette sub-family B (MDR/TAP) gene (TAP1) is located in the major histocompatibility complex class II region, and forms a heterodimer that plays a key role in endogenous antigen presentation pathways. Investigation of polymorphisms identified in these loci has revealed an association with several autoimmune disorders. Alopecia areata (AA) is a common autoimmune disease resulting from T cell-induced damage to hair follicles. The present study documents for the first time a comparison between the allelic and genotypic frequencies of TAP1 single nucleotide polymorphisms (SNPs) in patients with AA and those of a control group, using a direct sequencing method. Our results suggest an association between a promoter SNP (rs2071480) and susceptibility to this disease.
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