Glycine Reverses DNA Damage / Aging (even in a 97 year old's cells)

Commentary

"This led the scientists to suggest that perhaps it was so-called “epigenetic” factors, such as the addition of certain proteins to the mitochondrial DNA, which might be creating the defects that cause the signs of aging. If this were the case - the researchers purposed - then “resetting” the cell lines to stem cells would correct and remove these epigenetic factors. When they tested this with the cell lines from the older people, this is exactly what they found. Quite amazingly, it seemed to turn the “old” cells back into “young” ones. When they looked further into the sections of DNA that might be influenced by these epigenetic factors, their results pointed to two regions that control the production of a particular amino acid. The amino acid in question is called glycine. What’s more, when they then bathed the cell line derived from a 97-year-old in glycine for ten days, it restored the mitochondria’s ability to produce energy and reversed some age related defects."

Study

Epigenetic regulation of the nuclear-coded GCAT and SHMT2 genes confers human age-associated mitochondrial respiration defects

Age-associated accumulation of somatic mutations in mitochondrial DNA (mtDNA) has been proposed to be responsible for the age-associated mitochondrial respiration defects found in elderly human subjects. We carried out reprogramming of human fibroblast lines derived from elderly subjects by generating their induced pluripotent stem cells (iPSCs), and examined another possibility, namely that these aging phenotypes are controlled not by mutations but by epigenetic regulation. Here, we show that reprogramming of elderly fibroblasts restores age-associated mitochondrial respiration defects, indicating that these aging phenotypes are reversible and are similar to differentiation phenotypes in that both are controlled by epigenetic regulation, not by mutations in either the nuclear or the mitochondrial genome. Microarray screening revealed that epigenetic downregulation of the nuclear-coded GCAT gene, which is involved in glycine production in mitochondria, is partly responsible for these aging phenotypes. Treatment of elderly fibroblasts with glycine effectively prevented the expression of these aging phenotypes.

http://www.nature.com/srep/2015/150522/srep10434/full/srep10434.html

Columbo wrote:Commentary

"This led the scientists to suggest that perhaps it was so-called “epigenetic” factors, such as the addition of certain proteins to the mitochondrial DNA, which might be creating the defects that cause the signs of aging. If this were the case - the researchers purposed - then “resetting” the cell lines to stem cells would correct and remove these epigenetic factors. When they tested this with the cell lines from the older people, this is exactly what they found. Quite amazingly, it seemed to turn the “old” cells back into “young” ones. When they looked further into the sections of DNA that might be influenced by these epigenetic factors, their results pointed to two regions that control the production of a particular amino acid. The amino acid in question is called glycine. What’s more, when they then bathed the cell line derived from a 97-year-old in glycine for ten days, it restored the mitochondria’s ability to produce energy and reversed some age related defects."

Study

Epigenetic regulation of the nuclear-coded GCAT and SHMT2 genes confers human age-associated mitochondrial respiration defects

Age-associated accumulation of somatic mutations in mitochondrial DNA (mtDNA) has been proposed to be responsible for the age-associated mitochondrial respiration defects found in elderly human subjects. We carried out reprogramming of human fibroblast lines derived from elderly subjects by generating their induced pluripotent stem cells (iPSCs), and examined another possibility, namely that these aging phenotypes are controlled not by mutations but by epigenetic regulation. Here, we show that reprogramming of elderly fibroblasts restores age-associated mitochondrial respiration defects, indicating that these aging phenotypes are reversible and are similar to differentiation phenotypes in that both are controlled by epigenetic regulation, not by mutations in either the nuclear or the mitochondrial genome. Microarray screening revealed that epigenetic downregulation of the nuclear-coded GCAT gene, which is involved in glycine production in mitochondria, is partly responsible for these aging phenotypes. Treatment of elderly fibroblasts with glycine effectively prevented the expression of these aging phenotypes.

http://www.nature.com/srep/2015/150522/srep10434/full/srep10434.html

Looks like gelatin is the food highest in glycine. Unfortunately, it also contains a lot of fluoride.

glycine powder tastes lik sugar and can be used in coffee

iuyyighghghgkh wrote:glycine powder tastes lik sugar and can be used in coffee

Thanks. Do you know what it's made from?

Delphine wrote:

iuyyighghghgkh wrote:glycine powder tastes lik sugar and can be used in coffee

Thanks.  Do you know what it's made from?

corn or soybeans i assume

Was reading this and it reminded me of this thread. I have begun taking 12 grams of glycine per day.

http://www.theguthealthprotocol.com/wp/glycine-the-most-important-inflammation-regulator/

Yeah... I have been reading up on this too. I was mainly reading up on the gelatin side of things and that steered me toward L-Glycine. I am interested in adding this supplement, but wanted to get some opinions. It kind of makes sense to me that with the gelatin, we do not consume the parts of the animal that contains this naturally.

So, would a supplement like this be good to add - http://www.iherb.com/Source-Naturals-Glycine-500-mg-200-Capsules/1235

Thanks

Renky wrote:Yeah... I have been reading up on this too. I was mainly reading up on the gelatin side of things and that steered me toward L-Glycine. I am interested in adding this supplement, but wanted to get some opinions. It kind of makes sense to me that with the gelatin, we do not consume the parts of the animal that contains this naturally.

So, would a supplement like this be good to add - http://www.iherb.com/Source-Naturals-Glycine-500-mg-200-Capsules/1235

Thanks

I'd recommend the pure powder with nothing added. I'm using NOW brand. Does double duty as a mild sweetener.

I always prefer capsules if possible, so are you saying powder works better?

Thanks.

Renky wrote:I always prefer capsules if possible, so are you saying powder works better?

Thanks.

Not better necessary, but way cheaper and without any expedients in bulk. You can get 1 kilos (2.2lb) for $25. Glycine is easily my top ten health supplement.

4039 wrote:

Renky wrote:I always prefer capsules if possible, so are you saying powder works better?

Thanks.

Not better necessary, but way cheaper and without any expedients in bulk. You can get 1 kilos (2.2lb) for $25. Glycine is easily my top ten health supplement.

OK, what's your source for the kilo at $25? Thanks...

4039 wrote:

Renky wrote:I always prefer capsules if possible, so are you saying powder works better?

Thanks.

Not better necessary, but way cheaper and without any expedients in bulk. You can get 1 kilos (2.2lb) for $25. Glycine is easily my top ten health supplement.

Curious, what's your other 9?