Clinical use of conditioned media of adipose tissue-derived stem cells in female pattern hair loss: a retrospective case series study.

Int J Dermatol. 2015 Mar 16. doi: 10.1111/ijd.12650. [Epub ahead of print]
Clinical use of conditioned media of adipose tissue-derived stem cells in female pattern hair loss: a retrospective case series study.
Shin H1, Ryu HH, Kwon O, Park BS, Jo SJ.

BACKGROUND:
Female pattern hair loss (FPHL) is a common disorder but presents severe psychosocial problems in many female patients. Adipose tissue-derived stem cells (ADSCs) and conditioned media of ADSCs (ADSC-CM) are reported to promote hair growth in vitro. However, there are no clinical reports on the treatment of alopecia using ADSC-CM.
OBJECTIVES:
This study evaluates our clinical experience in the use of ADSC-CM for the treatment of FPHL.
METHODS:
A retrospective, observational study of outcomes in 27 patients with FPHL treated with ADSC-CM was performed. To evaluate the efficacy of the treatment, patients' medical records and phototrichographic images were analyzed.
RESULTS:
The application of ADSC-CM showed efficacy in treating FPHL after 12 weeks of therapy. Hair density increased from 105.4 to 122.7 hairs/cm2 (P < 0.001). Hair thickness increased from 57.5 μm to 64.0 μm (P < 0.001). None of the patients reported severe adverse reactions.
CONCLUSIONS:
The application of ADSC-CM is a potential treatment option for FPHL.