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Follicular streamers (stelae) in scarring and non-scarring alopecia

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Follicular streamers (stelae) in scarring and non-scarring alopecia Empty Follicular streamers (stelae) in scarring and non-scarring alopecia

Post  CausticSymmetry on Tue Jul 15, 2008 5:19 pm

J Cutan Pathol. 2008 Jun 19.
Follicular streamers (stelae) in scarring and non-scarring alopecia.
Horenstein MG, Jacob JS.

Dermatopathology Service, The Dermatology Group, Verona, NJ, USA.

Background: Follicular streamers are residual fibrovascular tracts representing the impermanent lower third of the hair follicle below the bulge region. Streamers are generally not counted in transverse alopecia samples as they may represent catagen/telogen (CT) follicles and vellus-like (VL) follicles, or be mistaken as follicular scars. Design: We evaluated 22 non-scarring alopecia cases, including alopecia areata (AA) and androgenetic alopecia (AGA), and 22 scarring alopecia cases, including follicular degeneration syndrome (FDS)/central centrifugal cicatricial alopecia and other scarring alopecia (OSA) disorders. We counted terminal follicular streamers found at a deep dermal level (L2) and followed them into a mid-dermal level at the central follicular unit (FU) to determine their precise derivation. Results: We found streamers in 8/9 AA, 11/13 AGA, 6/12 FDS and 3/10 OSA cases. We counted a total of 74 streamers at L2, including 61 in non-scarring alopecia cases (p < 0.001). At the more superficial FU level, 72% of streamers corresponded to CT follicles, 25% to VL follicles and 3% to follicular scars. Conclusions: Follicular streamers are found predominantly in non-scarring alopecia cases. Streamers found at deep dermal or subcutaneous levels should be followed and identified at the FU level in order to obtain accurate follicular counts and follicular ratios needed for non-scarring alopecia diagnosis.
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Follicular streamers (stelae) in scarring and non-scarring alopecia Empty Re: Follicular streamers (stelae) in scarring and non-scarring alopecia

Post  hadrion on Wed Jul 16, 2008 10:24 am

IH,

I'm having a hard time interpreting this. What does this study indicate?

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Follicular streamers (stelae) in scarring and non-scarring alopecia Empty Re: Follicular streamers (stelae) in scarring and non-scarring alopecia

Post  CausticSymmetry on Wed Jul 16, 2008 11:15 am

Probably the easiest way to describe Follicular streamers are like imagining banana strings infiltrating the housing of the follicle. The study points towards a way of differentiating between scaring and non-scaring hair loss, by observing the presence of these follicular streamers.

What is sometimes called perifollicular fibrosis are these "banana strings," but they are layers of fibrotic collagen of a mild sort and not considered fibrosis or scaring at that point. So far, it is not known if these temporarily or permanent.

These are probably the result of microorganisms creating micro inflammation.
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Post  isaac on Wed Jul 16, 2008 2:45 pm

As you explained Immortal E/Cava is you're top supp for this mico-inflammation yes?

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Post  CausticSymmetry on Wed Jul 16, 2008 2:51 pm

isaac - Yes, definitely. Most of the reasons are explained on the main page here:

http://www.freewebs.com/immortalhair/theoryinpractice.htm

"The value of Ecklonia Cava (Seanol).

The most powerful inhibitor of Matrix Metalloproteinase-9 (MMP-9) is a brown algae-based polyphenol, called Ecklonia Cava. It is a brown algae which grows at a depth of about 100 feet. Seanol is effectively extracted from Ecklonia Cava and has an interconnected phenolic ring structure capable of trapping ten to 100 times the free radicals of either Green tea and Resveratrol extracts.

Life Sci. 2006 Sep 5;79(15):1436-43.

Ecklonia Cava is also known as a phlorotannin and is 40% fat soluble, this means it acts as both a water and fat soluble anti-oxidant. Ecklonia cava is by far the most versatile supplement I've ever discovered to treat hair loss. Besides it potent inhibition of MMP-9, it effects a whole array of systems.
The polyphenols of Ecklonia cava can last up to 12 hours in human metabolism, while compared to most plant-based tannins have a half-life of just 30 minutes. Ecklonia cava's oxygen radical absorbance capacity (ORAC) value, the score for anti-oxidation potential is 8,300, is much higher than most land-based polyphenols.

Ecklonia Cava is one of the most powerful and versatile plant tannins in existence. It's been found to regulate cortisol, lower blood pressure, increase growth hormone levels, lower triglycerides, provides anti-inflammatory effects by a variety of mechanisms, such as inhibition of the NF-kB inflammatory pathway which also serves to normalize blood glucose levels.

The benefits do not end there, besides its ability to penetrate the blood-brain-barrier, offering protection against oxidative stress, it also offers a significant increase in trans-cranial blood flow giving powerful release in alpha brain waves and parasympathetic nerve response. This creates a heightened sense of relaxation and mental alertness. Animal research shows positive increases in gamma-aminobutyric acid (GABA), noripenepherine and serotonin levels. A large number of human users report improved sleep. Personally, I find the beneficial effects to my hair to be the most rewarding.

You might think the benefits end there, not so fast. In addition, this phlorotannin posesses a potent anti-plasmin inhibition activity, which results in thinner blood viscosity. Generally, the thinner our blood, the longer we live. Ecklonia cava helps maintain normal blood pressure and has been comparable to the ACE inhibitor drug, enalapril.

Recently, it was found that high blood pressure is strongly associated with androgenetic hair loss.

Eur J Dermatol. 2007 May-Jun;17(3):220-2.

Ecklonia Cava has potent anti-DGAT activity. Diacylglycerol acyltransferase or DGAT is an enzyme that catalyzes triacylgycerol in adipocytes, hence the inhibition of this is currently being explored as drug targets for help with obesity. Unlike Ecklonia cava, drugs with this ability have serious side effects. Last but, certainly not least, Ecklonia Cava helps prevent premature wrinkling by increasing the enzyme activity of elastase."
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Follicular streamers (stelae) in scarring and non-scarring alopecia Empty Re: Follicular streamers (stelae) in scarring and non-scarring alopecia

Post  hadrion on Wed Jul 16, 2008 4:40 pm

CausticSymmetry wrote:Probably the easiest way to describe Follicular streamers are like imagining banana strings infiltrating the housing of the follicle. The study points towards a way of differentiating between scaring and non-scaring hair loss, by observing the presence of these follicular streamers.

What is sometimes called perifollicular fibrosis are these "banana strings," but they are layers of fibrotic collagen of a mild sort and not considered fibrosis or scaring at that point. So far, it is not known if these temporarily or permanent.

These are probably the result of microorganisms creating micro inflammation.

Do these streamers ever break through the scalp as if they were hair?

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Post  CausticSymmetry on Wed Jul 16, 2008 4:49 pm

hadrion - As far as I know they only exist in the lower layers in the skin and underneath it.
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