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The effect of dietary modulation of sulfur amino acids on cystathionine β synthase-deficient mice. EmptyToday at 4:25 am by shaftless

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The effect of dietary modulation of sulfur amino acids on cystathionine β synthase-deficient mice. EmptySat Mar 23, 2024 10:25 am by CausticSymmetry

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The effect of dietary modulation of sulfur amino acids on cystathionine β synthase-deficient mice.

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The effect of dietary modulation of sulfur amino acids on cystathionine β synthase-deficient mice. Empty The effect of dietary modulation of sulfur amino acids on cystathionine β synthase-deficient mice.

Post  CausticSymmetry Thu Jun 27, 2019 9:15 am

Ann N Y Acad Sci. 2016 Jan;1363:80-90. doi: 10.1111/nyas.12967. Epub 2015 Nov 24.
The effect of dietary modulation of sulfur amino acids on cystathionine β synthase-deficient mice.
Kruger WD1, Gupta S1.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.

Cystathionine β synthase (CBS) is a key enzyme in the methionine and cysteine metabolic pathway, acting as a metabolic gatekeeper to regulate the flow of fixed sulfur from methionine to cysteine. Mutations in the CBS gene cause clinical CBS deficiency, a disease characterized by elevated plasma total homocysteine (tHcy) and methionine and decreased plasma cysteine. The treatment goal for CBS-deficient patients is to normalize the metabolic values of these three metabolites using a combination of vitamin therapy and dietary manipulation. To better understand the effectiveness of nutritional treatment strategies, we have performed a series of long-term dietary manipulation studies using our previously developed Tg-I278T Cbs(-/-) mouse model of CBS deficiency and sibling Tg-I278T Cbs(+/-) controls. Tg-I278T Cbs(-/-) mice have undetectable levels of CBS activity, extremely elevated plasma tHcy, modestly elevated plasma methionine, and low plasma cysteine. They exhibit several easily assayable phenotypes, including osteoporosis, loss of fat mass, reduced life span, and facial alopecia. The diets used in these studies differed in the amounts of sulfur amino acids or sulfur amino acid precursors. In this review, we will discuss our findings and their relevance to CBS deficiency and the concept of gene-diet interaction.

Full Study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801721/

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The effect of dietary modulation of sulfur amino acids on cystathionine β synthase-deficient mice. Empty Re: The effect of dietary modulation of sulfur amino acids on cystathionine β synthase-deficient mice.

Post  NYJets Fri Jul 05, 2019 7:52 am

TLDR; Supplement NAC alongside ALA+ALCAR?
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The effect of dietary modulation of sulfur amino acids on cystathionine β synthase-deficient mice. Empty Re: The effect of dietary modulation of sulfur amino acids on cystathionine β synthase-deficient mice.

Post  CausticSymmetry Wed Jul 10, 2019 12:13 pm

NYJets wrote:TLDR; Supplement NAC alongside ALA+ALCAR?

Not exactly, no.

Would take the time to read the full study.


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