Search
 
 

Display results as :
 


Rechercher Advanced Search

Check Out Our Sponsors
Brought to you by
Hair Loss Forum
Navigation
 Portal
 Index
 Memberlist
 Profile
 FAQ
 Search
Latest topics
Navigation
 Portal
 Index
 Memberlist
 Profile
 FAQ
 Search

Secreted Frizzled-related protein 4 inhibits the regeneration of hair follicles.

Go down

Secreted Frizzled-related protein 4 inhibits the regeneration of hair follicles. Empty Secreted Frizzled-related protein 4 inhibits the regeneration of hair follicles.

Post  CausticSymmetry on Tue Jan 22, 2019 4:19 am

PeerJ. 2019 Jan 4;6:e6153. doi: 10.7717/peerj.6153. eCollection 2019.
Secreted Frizzled-related protein 4 inhibits the regeneration of hair follicles.
Guo H1, Xing Y1, Deng F1, Yang K2, Li Y1.

Secreted Frizzled-related Protein 4 (sFRP4) belongs to Wnt inhibitors. Previously, we reported that sFRP4 inhibited the differentiation of melanocyte. Here, by using of immunostaining, we showed that sFRP4 is expressed in both human and mouse hair follicles, especially in the outer root sheath and inner root sheath. To reveal the role of sFRP4 in hair follicle growth and hair cycle, we induced synchronized hair cycle in the dorsal skin of mice by depilation, and injected sFRP4 intradermally into the skin. By hematoxylin and eosin staining, we found that the regeneration of hair follicles was inhibited by sFRP4. However, the structure of hair follicles remained complete. Compared with phosphate buffer saline-treated hair follicles, the sFRP4-treated hair follicles still had the same expression pattern of keratins. Our findings reveal that sFRP4 inhibits but not blocks the regeneration of hair follicles, and supply a potential therapeutic application to treat hair follicle regeneration disorders.

KEYWORDS:
Hair follicle; Keratin; Wnt signaling pathway; sFRP4

Full: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322481/

_________________
My regimen
http://www.immortalhair.org/mpb-regimen

Now available for consultation (hair and/or health)
http://www.immortalhair.org/health-consultation
CausticSymmetry
CausticSymmetry
Admin

Posts : 12186
Join date : 2008-07-09

View user profile http://www.immortalhair.org/

Back to top Go down

Back to top

- Similar topics

 
Permissions in this forum:
You cannot reply to topics in this forum